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Comparison of Outcomes of Hinge Craniotomy Versus Decompressive Craniectomy in Patients With Malignant Intracranial Hypertension: A Prospective, Randomized Controlled Study.
Korean J Neurotrauma
December 2024
Department of Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Objective: This randomized controlled trial (RCT) aimed to compare the short-, mid-, and long-term outcomes in patients with malignant intracranial hypertension undergoing either decompressive craniectomy (DC) or hinge craniotomy (HC).
Methods: In this prospective RCT, 38 patients diagnosed with malignant intracranial hypertension due to ischemic infarction, traumatic brain injury, or non-lesional spontaneous intracerebral hemorrhage, who required cranial decompression, were randomly allocated to the DC and HC groups.
Results: The need for reoperation, particularly cranioplasty, in the DC group was significantly different from that in the HC group.
Exploring the Obesity Paradox in All Subtypes of Intracranial Hemorrhage: A Retrospective Cohort Analysis of 13,000 Patients.
Brain Sci
November 2024
School of Medicine, New York Medical College, Valhalla, NY 10595, USA.
Background/objectives: Recent studies reveal an "obesity paradox", suggesting better clinical outcomes after intracranial hemorrhage for obese patients compared to patients with a healthy BMI. While this paradox indicates improved survival rates for obese individuals in stroke cases, it is unknown whether this trend remains true across all forms of intracranial hemorrhage. Therefore, the objective of our study was to investigate the incidence, characteristics, and outcomes of hospitalized obese patients with intracranial hemorrhage.
View Article and Find Full Text PDFEfficacy of minimally invasive hematoma evacuation in treating traumatic intracranial hematoma: a retrospective cohort study.
Neurol Sci
January 2025
Department of Neurosurgery, Shengli Oilfield Center Hospital, Dongying, Shandong, 257099, China.
Article Synopsis
- This study evaluated the effectiveness and safety of minimally invasive hematoma evacuation versus craniotomy for treating traumatic intracranial hematomas in 90 patients.
- Results showed that the minimally invasive group had a higher good prognosis rate (86.67% vs. 68.89%), lower NIHSS scores, and significantly reduced hospitalization costs and times compared to the craniotomy group.
- The findings suggest that minimally invasive procedures may offer benefits like less surgical trauma and fewer complications, improving recovery for patients with traumatic intracranial hematomas.
Harmine-induced disruption of the blood-brain barrier via excessive mitophagy in zebrafish.
Eur J Pharmacol
February 2025
School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address:
Stroke is a serious condition with sudden onset, high severity, and significant rates of mortality and disability, ranking as the second leading cause of death globally at 11.6%. Hemorrhagic stroke, characterized by non-traumatic rupture of cerebral vessels, can cause secondary brain injury such as neurotoxicity, inflammation, reactive oxygen species, and blood-brain barrier (BBB) damage.
View Article and Find Full Text PDFThe Historical and Clinical Foundations of the Modern Neuroscience Intensive Care Unit.
World Neurosurg
December 2024
Clinical and Translational Neuroscience Unit, Department of Neurology and Feil Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA. Electronic address:
The subspecialty of neurocritical care has grown significantly over the past 40 years along with advancements in the medical and surgical management of neurological emergencies. The modern neuroscience intensive care unit (neuro-ICU) is grounded in close collaboration between neurointensivists and neurosurgeons in the management of patients with such conditions as ischemic stroke, aneurysmal subarachnoid hemorrhage, intracerebral hemorrhage, subdural hematomas, and traumatic brain injury. Neuro-ICUs are also capable of specialized monitoring such as serial neurological examinations by trained neuro-ICU nurses; invasive monitoring of intracranial pressure, cerebral oxygenation, and cerebral hemodynamics; cerebral microdialysis; and noninvasive monitoring, including the use of pupillometry, ultrasound monitoring of optic nerve sheath diameters, transcranial Doppler ultrasonography, near-infrared spectroscopy, and continuous electroencephalography.
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