Rice can be a major contributor to dietary arsenic exposure because of the relatively high total arsenic concentration compared to other grains, especially for people whose main staple is rice. This study employed in vitro gastrointestinal fluid digestion to determine bioaccessible or gastrointestinal fluid extractable arsenic concentration in rice. Thirty-one rice samples, of which 60 % were grown in the United States, were purchased from food stores in New York City. Total arsenic concentrations in these samples ranged from 0.090 ± 0.004 to 0.85 ± 0.03 mg/kg with a mean value of 0.275 ± 0.161 mg/kg (n = 31). Rice samples with relatively high total arsenic (>0.20 mg/kg, n = 18) were treated by in vitro artificial gastrointestinal fluid digestion, and the extractable arsenic ranged from 53 % to 102 %. The bioaccessibility of arsenic in rice decreases in the general order of extra long grain, long grain, long grain parboiled, to brown rices.
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http://dx.doi.org/10.1080/03601234.2012.611431 | DOI Listing |
Cancer Immunol Immunother
January 2025
Public Center of Experimental Technology, The School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
Although immune checkpoint inhibitors have changed the treatment paradigm for non-small cell lung cancer (NSCLC), not all patients benefit from them. Therefore, there is an urgent need to explore novel immune checkpoint inhibitors. Neuropilin-1 (Nrp-1) is a unique immune checkpoint capable of exerting antitumor effects through CD8 T cells.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Background: The brain is shielded from the peripheral circulation by central nervous system (CNS) barriers, comprising the well-known blood-brain barrier (BBB) and the less recognized blood-cerebrospinal fluid (CSF) barrier located within the brain ventricles. The gut microbiota represents a diverse and dynamic population of microorganisms that can influence the health of the host, including the development of neurological disorders like Alzheimer's disease (AD). However, the intricate mechanisms governing the interplay between the gut and brain remain elusive, and the means by which gut-derived signals traverse the CNS barriers remain unclear.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Background: The gut microbiota and microglia play critical roles in Alzheimer's disease (AD), and more information is needed on how specific bacteria affect brain immunity in AD. We found that Bacteroides increased in aging Tg2576 mice and correlated with amyloid-beta (Aβ) plaques and hypothesized that Bacteroides worsens AD pathology by modulating microglia. Bacteroides is also elevated in AD patients and correlates with cerebrospinal fluid levels of Aβ and tau.
View Article and Find Full Text PDFPharm Dev Technol
January 2025
Univ Angers, INSERM, CNRS, MINT, SFR ICAT, France.
This work explores two methods to encapsulate Thymoquinone (TQ) into lipid nanocapsules (LNCs) for oral administration. TQ was added during the phase inversion temperature method (TQ-LNCs-1) or to unload LNCs dispersion (TQ-LNCs-2). LNCs were evaluated for mean diameter, polydispersity index (PDI), ζ-potential, drug loading (DL), drop tensiometer, storage stability, stability in simulated gastrointestinal fluids (SGIF), and intestinal permeability across Caco-2 cells.
View Article and Find Full Text PDFCureus
December 2024
Gastroenterology and Hepatology, Saint Peter's University Hospital, New Brunswick, USA.
Acute esophageal necrosis (AEN), also known as black esophagus or Gurvits syndrome, is an uncommon endoscopic finding characterized by diffuse, circumferential, black discoloration of the esophagus that terminates at the gastroesophageal junction. The incidence of AEN has been reported to be 0-0.2% in autopsy series and up to 0.
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