One of the major objectives in metabolomics is the identification of subtle changes in metabolite profiles as affected by genetic or environmental factors. Comprehensive two-dimensional gas chromatography (GC × GC) hyphenated to a fast-acquisition mass spectrometer is a well-established analytical technique to study the composition of complex samples due to its enhanced separation capacity, sensitivity, peak resolution, and reproducibility. This review reports applications of GC × GC to metabolomics studies of sample of different types (biofluid, cells, tissue, bacteria, yeast, plants), and discusses its advantages and limitations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00216-011-5630-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Overview and Prospects of DNA Sequence Visualization.
Int J Mol Sci
January 2025
School of Mathematics and Computer Science, Gannan Normal University, Ganzhou 341000, China.
Due to advances in big data technology, deep learning, and knowledge engineering, biological sequence visualization has been extensively explored. In the post-genome era, biological sequence visualization enables the visual representation of both structured and unstructured biological sequence data. However, a universal visualization method for all types of sequences has not been reported.
View Article and Find Full Text PDFIn Vitro Evaluation of the Safety and Efficacy of Using Adult Stem Cell-Derived Organoids and Colorectal Cancer Spheroids.
Cancers (Basel)
January 2025
Doppl SA, 1015 Lausanne, Switzerland.
: Developing ex vivo models that replicate immune-tumor interactions with high fidelity is essential for advancing immunotherapy research, as traditional two-dimensional in vitro systems often lack the complexity required to fully represent these interactions. : In this study, we establish a comprehensive 3D redirect lysis (3D-RDL) assay using colorectal cancer spheroids and adult stem cell-derived, healthy human organoids to evaluate the efficacy and safety profile of , a bispecific antibody targeting carcinoembryonic antigens (CEAs) on cancer cells and CD3 on T cells. This model allows us to assess cytotoxic activity and immune responses, capturing variations in therapeutic response not observable in simpler systems.
View Article and Find Full Text PDFComprehensive Characterization of the Odor-Active Compounds in Different Processed Varieties of Yunnan White Tea () by GC×GC-O-MS and Chemometrics.
Foods
January 2025
College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
This study investigates the aroma characterization of unique white tea varieties from the Lüchun county of Yunnan province, Mainland China. These include shaken, unshaken, steam-cooked, and compressed varieties. The aroma profile of white tea varieties was analyzed using two-dimensional gas chromatography-olfactometry-mass spectrometry (GC×GC-O-MS), electronic nose (e-nose), and descriptive sensory evaluation.
View Article and Find Full Text PDFA New Graphical Method for Displaying Two-Dimensional Echocardiography Results in Dogs: Comprehensive Analysis of Results of Diagnostic Imaging Organized in a BOX (CARDIOBOX).
Vet Sci
January 2025
Internal Medicine, Veterinary Medicine and Therapeutic Research Group, Faculty of Veterinary Science, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, 35413 Las Palmas de Gran Canaria, Spain.
Introduction And Objective: Rapid and efficient interpretation of echocardiographic findings is critical in clinical decision-making. This study aimed to design and validate a new graphical method, called CARDIOBOX, to represent echocardiographic findings in dogs.
Methods: A prospective, observational, exploratory cohort study was conducted over three years.
Evaluation of Machine Learning Algorithms for Classification of Visual Stimulation-Induced EEG Signals in 2D and 3D VR Videos.
Brain Sci
January 2025
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Backgrounds: Virtual reality (VR) has become a transformative technology with applications in gaming, education, healthcare, and psychotherapy. The subjective experiences in VR vary based on the virtual environment's characteristics, and electroencephalography (EEG) is instrumental in assessing these differences. By analyzing EEG signals, researchers can explore the neural mechanisms underlying cognitive and emotional responses to VR stimuli.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!