ONZIN is abundantly expressed in immune cells of both the myeloid and lymphoid lineage. Expression by lymphoid cells has been reported to further increase after cutaneous exposure of mice to antigens and haptens capable of inducing contact hypersensitivity (CHS), suggesting that ONZIN has a critical role in this response. Here, we report that indeed ONZIN-deficient mice develop attenuated CHS to a number of different haptens. Dampened CHS responses correlated with a significant reduction in pro-inflammatory IL-6 at the challenge site in ONZIN-deficient animals, compared with wild-type controls. Together the study of these animals indicates that loss of ONZIN impacts the effector phase of the CHS response through the regulation of pro-inflammatory factors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336033 | PMC |
| http://dx.doi.org/10.1038/icb.2011.107 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Para-Phenylenediamine-Induced Lichenoid Eruption With Involvement of the Oral Mucosa and Subsequent Contact Leukoderma.
Dermatitis
January 2025
From the Dermatology Department, Fattouma Bourguiba University Hospital, Dermo-respiratory Research Laboratory LR20SP003, Monastir, Tunisia.
Allergic Contact Dermatitis From Colophonium in Upholstery Adhesive: Two Case Reports of a Novel Source.
Contact Dermatitis
January 2025
Department of Dermatology and Venereology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Türkiye.
Toluene-2,5-Diamine Sulfate: Allergen of the Year 2025.
Dermatitis
January 2025
Department of Dermatology, University of California, San Francisco, California, USA.
Toluene-2,5-diamine sulfate (PTDS), also known as toluene diamine sulfate or 2,5-diaminotoluene sulfate, is an aromatic amine that can be used as a paraphenylenediamine (PPD) hair dye alternative. Patients may develop contact allergy to PTDS, and it is often omitted from standard patch test screening series, possibly leading to underdiagnosis. The American Contact Dermatitis Society named PTDS the Allergen of the Year for 2025, aiming to raise awareness of its dual role as both an allergen and an alternative for some PPD-allergic individuals.
View Article and Find Full Text PDFPOLYPHARMACY AND CANCER: А NEW VISION FOR SKIN CANCER PATHOGENESIS-PHOTOTOXICITY AND PHOTOCARCINOGENICITY DUE TO NITROSAMINE CONTAMINATION DURING TELMISARTAN/ TAMSULOSIN INTAKE.
Georgian Med News
November 2024
4Department of Pathology, University of Virginia, Charlottesville, USA.
The toxicokinetics of nitrosamines remain a mystery to this day, though it appears that the role of nitrosamines in potentiating the generation of mutations required for the onset of skin cancer continues to be a significant concern. Nitrosamines are mutagens, genotoxic substances, and mediators of phototoxicity/carcinogenicity, whose long-term daily usage, in the context of polypharmacy, can result in the parallel appearance of heterogeneous forms of skin cancer: keratinocytic and melanocytic. But a number of clinical observations suggest that it is the nitrosamines that potentiate the multiple occurrences of skin cancer over the years, or recurrences of skin cancer localized in areas exposed to solar radiation.
View Article and Find Full Text PDFConsideration of the work environment in a case of an industrial homeworker with allergic contact dermatitis by UV-curing acrylic resin.
Arch Environ Occup Health
January 2025
Department of Oral Epidemiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima-city, Hiroshima, Japan.
We report a case of an industrial homeworker diagnosed with allergic contact dermatitis by UV-curing acrylic resin for crafts. Approximately 2 months after a female in her 40s started producing handicrafts using resin, itchy desquamative erythema and vesicles occurred on her eyelids and palms. The course of the symptoms suggested that her dermatitis was occupational origin.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!