AI Article Synopsis
- The study focuses on the characterization of an oxovanadium(IV) complex involving oxodiacetic acid and o-phenanthroline, revealing its unique tridentate OOO coordination.
- The biological effects of this complex were tested on two types of osteoblast-like cells, specifically MC3T3E1 (normal) and UMR106 (tumoral) cells.
- The results indicated that the complex inhibited cell proliferation more significantly in the normal MC3T3E1 cells compared to the tumoral UMR106 cells.
Article Abstract
The oxovanadium(IV) complex of oxodiacetic acid (H(2)ODA) and o-phenanthroline of stoichiometry [VO(ODA)(ophen)]·1.5H(2)O, which presents the interesting tridentate OOO coordination, was thoroughly characterized by infrared, Raman, and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast cell lines in culture, but the cytotoxicity was stronger in the normal (MC3T3E1) than in the tumoral (UMR106) osteoblasts.
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| http://dx.doi.org/10.1007/s12011-012-9322-z | DOI Listing |
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