Immunoreactive oxytocin (IR-OXT) detected in extracts of human lumbar sympathetic paravertebral ganglia was characterized by high-performance liquid chromatography (HPLC). The immunoreactive substance was found to elute at the same position as the reference preparation of oxytocin (OXT). The results revealed the presence of chromatographically identified OXT in human sympathetic ganglia.

Download full-text PDF

Source
http://dx.doi.org/10.1016/0006-8993(90)91477-xDOI Listing

Publication Analysis

Top Keywords

human sympathetic
8
sympathetic paravertebral
8
paravertebral ganglia
8
characterization oxytocin
4
oxytocin immunoreactivity
4
immunoreactivity human
4
ganglia immunoreactive
4
immunoreactive oxytocin
4
oxytocin ir-oxt
4
ir-oxt detected
4

Similar Publications

Sex-Specific Differences in the Pathophysiology of Hypertension.

Biomolecules

January 2025

Department of Physiology and Pathophysiology, St. Boniface Hospital Albrechtsen Research Centre, Institute of Cardiovascular Sciences, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Rm. 3042, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada.

Hypertension is one of the most common comorbidities in cardiometabolic diseases, affecting nearly one third of adults. As a result, its pathophysiological mechanisms have been studied extensively and are focused around pressure natriuresis, the renin-angiotensin system (RAS), the sympathetic nervous system, oxidative stress, and endothelial dysfunction. Additionally, hypertension secondary to other underlying etiologies also exists.

View Article and Find Full Text PDF

Heart rate variability as a digital biomarker for frailty in cardiovascular patients.

J Frailty Aging

February 2025

Division of Experimental Medicine, McGill University, Montreal, QC Canada; Division of Cardiology, Jewish General Hospital, Montreal, QC Canada. Electronic address:

Background: Frailty is a syndrome associated with age-related impairments in multiple organ systems, of which the autonomic nervous system plays a fundamental role. Measurement of heart rate variability (HRV) is a non-invasive method to evaluate the autonomic activity and gain insights into cardiovascular health and potentially, frailty. A few small studies have explored the relationship between HRV and frailty, with promising but conflicting results.

View Article and Find Full Text PDF

The unique architecture of the liver consists of hepatic lobules, dividing the hepatic features of metabolism into 2 distinct zones, namely the pericentral and periportal zones, the spatial characteristics of which are broadly defined as metabolic zonation. R-spondin3 (Rspo3), a bioactive protein promoting the Wnt signaling pathway, regulates metabolic features especially around hepatic central veins. However, the functional impact of hepatic metabolic zonation, regulated by the Rspo3/Wnt signaling pathway, on whole-body metabolism homeostasis remains poorly understood.

View Article and Find Full Text PDF

Integrating respiration into sympathetic transduction to blood pressure.

J Physiol

January 2025

Human Cardiovascular Physiology Laboratory, Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.

View Article and Find Full Text PDF

Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth.

J Transl Med

January 2025

Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, P.R. China.

Background: The colon and rectum are highly innervated, with neural components within the tumor microenvironment playing a significant role in colorectal cancer (CRC) progression. While perineural invasion (PNI) is associated with poor prognosis in CRC, the impact of nerve density and diameter on tumor behavior remains unclear. This study aims to evaluate the prognostic value of nerve characteristics in CRC and to verify the impact of nerves on tumor growth.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!