A study was made of 819 patients attending a metabolic stone clinic. A firm diagnosis was made in 708 (86%) and in 132 of these (19%) the diagnosis was thought to be chronic dehydration. The records were available for study for 87 males and 11 females in the chronic dehydration group. The mean age at presentation was 43 years. The causes of chronic dehydration were hot climate (62%), with hot occupation and low water intake almost equal in second place. In patients with a single cause of chronic dehydration, 57% also had a dietary risk factor for urolithiasis and this was most commonly high oxalate intake. Following dietary advice, the mean urinary volume increased from 1720 to 2475 ml/24 h. This was accompanied by a rise in mean urinary calcium from 6.02 to 6.96 mmol/24 h, presumably due to the calcium in the additional water drunk. Urinary oxalate did not change significantly. The mean follow-up time was 4.85 years and the stone recurrence rate was low. It was concluded that chronic dehydration is a common cause of urolithiasis; this can be treated satisfactorily by increasing water intake plus dietary advice in certain cases.
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Appetite
March 2025
Department of Physiology & Pathology, School of Dentistry, São Paulo State University (UNESP), 14801-903 Araraquara, São Paulo, Brazil. Electronic address:
The intraperitoneal injection (ip) of N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine, MK-801, blocks sodium appetite sensitization in rats. Therefore, NMDA receptors seem important for ingestive behavioral adaptations to episodic or chronic periods of dehydration and salt depletion. Orofacial somatic motor responses to intraoral infusion of salt, in a salt taste reactivity test, can be an index of salt palatability.
View Article and Find Full Text PDFmBio
March 2025
Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator () gene, resulting in CFTR protein dysfunction. CFTR dysfunction has multi-organ consequences, leading to dehydrated mucus that is adherent to epithelia. In the lungs, this leads to recalcitrant infections with bacteria such as .
View Article and Find Full Text PDFCase Rep Dent
February 2025
Department of Stomatology, School of Dentistry, Federal University of Goiás, Goiânia, Goiás, Brazil.
Osteomyelitis is an infection caused by bacterial contamination of the bone marrow, cortical surfaces, and the periosteum. The clinical examination of a patient with severe osteomyelitis secondary to dental implants revealed a large facial swelling, suppuration in the perimandibular region, limited mouth opening, and diffuse pain that started after the placement of five dental implants. Two failed implants were removed, a reconstructive titanium plate was placed, and the patient was treated with antibiotics, but the infection did not resolve.
View Article and Find Full Text PDFJ Clin Med
February 2025
Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Children, particularly infants and those with chronic conditions, are highly vulnerable to heat-induced health risks, similarly to the elderly. This narrative review synthesizes current evidence on the impact of heat exposure on pediatric and perinatal health. A systematic literature search was conducted using PubMed/MEDLINE and manual reference checks, focusing on studies from 2000 to 2024.
View Article and Find Full Text PDFChildren (Basel)
January 2025
Department of Food Science and Technology, University of Patras, G Seferi 2, 30100 Agrinio, Greece.
Background/objectives: The importance of adequate hydration in children and adolescents has raised significant attention, both for its health benefits and for its role in supporting cognitive and physical performance. This is particularly important for young athletes who have increased dehydration risk due to high sweat loss and often inadequate water intake. The aim of this review is to systematically assess the hydration status of children and adolescents, including athletes, and to identify notable differences in hydration levels between these groups.
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