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Novel Design on Knee Exoskeleton with Compliant Actuator for Post-Stroke Rehabilitation.
Sensors (Basel)
December 2024
Institute of Robotics, Autonomous System and Sensing, School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT, UK.
Knee joint disorders pose a significant and growing challenge to global healthcare systems. Recent advancements in robotics, sensing technologies, and artificial intelligence have driven the development of robot-assisted therapies, reducing the physical burden on therapists and improving rehabilitation outcomes. This study presents a novel knee exoskeleton designed for safe and adaptive rehabilitation, specifically targeting bed-bound stroke patients to enable early intervention.
View Article and Find Full Text PDFThe Effects of Laxogenin and 5-Alpha-hydroxy-laxogenin on Myotube Formation and Maturation During Cultured Meat Production.
Int J Mol Sci
January 2025
Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Cultured meat (CM) is derived from the in vitro myogenesis of muscle satellite (stem) cells (MSCs) and offers a promising alternative protein source. However, the development of a cost-effective media formulation that promotes cell growth has yet to be achieved. In this study, laxogenin (LAX) and 5-alpha-hydroxy-laxogenin (5HLAX) were computationally screened against myostatin (MSTN), a negative regulator of muscle mass, because of their antioxidant properties and dual roles as MSTN inhibitors and enhancers of myogenesis regulatory factors.
View Article and Find Full Text PDFBrewers' Spent Grain-Derived Arabinoxylan as a Sustainable Filler for Enhanced PHBV Biocomposites.
Polymers (Basel)
January 2025
Department of Chemistry, Biology and Biotechnology, University of Perugia, 06123 Perugia, Italy.
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a highly promising biodegradable and bio-based thermoplastic recognized for its environmental benefits and potential versatility. However, its industrial adoption has been limited due to its inherent brittleness and suboptimal processability. Despite these challenges, PHBV's performance can be tailored for a wide range of applications through strategic modifications, particularly by blending it with other biodegradable polymers or reinforcing it with natural fibers and bio-based fillers.
View Article and Find Full Text PDFUnveiling the enzymatic pathway of UMG-SP2 urethanase: insights into polyurethane degradation at the atomic level.
Chem Sci
December 2024
LAQV@REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto Rua do Campo Alegre s/n 4169-007 Porto Portugal
The recently discovered metagenomic urethanases UMG-SP1, UMG-SP2, and UMG-SP3 have emerged as promising tools to establish a bio-based recycling approach for polyurethane (PU) waste. These enzymes are capable of hydrolyzing urethane bonds in low molecular weight dicarbamates as well as in thermoplastic PU and the amide bond in polyamide employing a Ser-Ser -Lys triad for catalysis, similar to members of the amidase signature protein superfamily. Understanding the catalytic mechanism of these urethanases is crucial for enhancing their enzymatic activity and improving PU bio-recycling processes.
View Article and Find Full Text PDFA portable optical detection system for rapid quantification of two rheumatoid arthritis biomarkers.
Anal Chim Acta
January 2025
Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan; Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes joint damage and progressive destruction of adjacent cartilage and bones. Quick and accurate detection of rheumatoid factors (RF) and anti-cyclic citrullinated peptide antibodies (anti-CCP) in serum is effective in diagnosing RA and preventing its progression. However, current methods for detecting these two biomarkers are costly, time-consuming, labor-intensive, and require specialized equipment.
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