AI Article Synopsis
- - A novel approach was created for designing artificial receptors that can specifically manage protein interactions using a combination of template-assisted methods and self-activating click reactions in a combinatorial library.
- - Researchers focused on synthetic versions of the Grb2-SH2 domain, which were used as a test case for this new strategy.
- - These synthetic mimics successfully attached to a target signaling protein, resulting in the induction of cell death and reduced tumor growth in living organisms.
Article Abstract
A new synthetic strategy for obtaining artificial receptors that selectively regulate and/or control specific protein/protein interactions was developed based on the template-assisted and the self-activating click reaction applied to a combinatorial library. Synthetic mimics of the Grb2-SH2 domain, examined as a model case, selectively bound to a target signaling protein to induce cytotoxicity and inhibit tumor growth in vivo.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/cb2003175 | DOI Listing |
Publication Analysis
Top Keywords
template-assisted self-activating
8
self-activating clicked
4
clicked peptide
4
peptide synthetic
4
synthetic mimic
4
mimic sh2
4
sh2 domain
4
domain synthetic
4
synthetic strategy
4
strategy obtaining
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!