The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors.

Beilstein J Org Chem

Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, Cambridgeshire, CB2 1EW, UK.

Published: August 2012

Herein we describe the application of a monolithic triphenylphosphine reagent to the Appel reaction in flow-chemistry processing, to generate various brominated products with high purity and in excellent yields, and with no requirement for further off-line purification.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252869PMC
http://dx.doi.org/10.3762/bjoc.7.194DOI Listing

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