The present case study reports the first case of a 38-year-old hairdresser with irritant-associated vocal cord dysfunction (VCD) due to alkaline persulfate, who was referred on suspicion of occupational asthma. Several tests were performed, including specific inhalation challenge and upper airway endoscopy. During the specific inhalation challenge to alkaline persulfate, the patient experienced dysphonia and a non-significant decrease in forced expiratory volume in 1 second on spirometry. Upper airway endoscopy was then performed and revealed VCD. A specific inhalation challenge test is therefore essential in cases of VCD to exclude possible concomitant occupational asthma.
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http://dx.doi.org/10.5588/ijtld.11.0315 | DOI Listing |
Clin Pharmacol Ther
January 2025
Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.
Comparisons of maximum drug concentration (C) and total area under the concentration vs. time curve (AUC) may be inadequate for bioavailability (BA)/bioequivalence (BE) assessments in cases where the shape of the pharmacokinetic (PK) profile of a drug impacts the clinical performance. In such cases, partial area under the concentration vs.
View Article and Find Full Text PDFEnviron Int
January 2025
State Key Laboratory of Marine Pollution and Department of Chemistry, City University of Hong Kong, Hong Kong 999077, China; Department of Applied Science, School of Science and Technology, Hong Kong Metropolitan University, Hong Kong 999077, China.
Despite the ubiquity and complexity of atmospheric polycyclic aromatic compounds (PACs), many of these compounds are largely unknown and lack sufficient toxicity data for comprehensive risk assessments. In this study, nontarget screening assisted by in-house and self-developed spectra databases was, therefore, employed to identify PACs in atmospheric particulate matter collected from multiple outdoor settings. Additionally, absorption, distribution, metabolism, excretion, and toxicity properties were evaluated to indicate PAC's overall abilities to cause adverse outcomes and incorporated into a novel health risk assessment model to assess their inhalation risks.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Bio & Healing Convergence, Konkuk University, Seoul, 05029, Republic of Korea.
This study investigated the psychophysiological and metabolomic changes during horticultural activities involving the inhalation of volatile organic compounds (VOCs) in individuals experiencing depressive mood based on the presence or absence of the soil microbe Streptomyces rimosus, which emits VOCs. Thirty participants met the specific depression and anxiety criteria and engaged in horticultural activities using soil inoculated with S. rimosus (experimental group) or medium (control group).
View Article and Find Full Text PDFBMJ Open
January 2025
Department of Plastic and Burn Surgery, Second Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, China
Objective: This study aimed to assess the impact of the COVID-19 pandemic on the characteristics and outcomes of patients with burns in a burn centre situated in Northwest China.
Design: A retrospective descriptive study.
Setting: This study was conducted in Tangdu Hospital, a major regional burn centre in Xi'an, Shaanxi Province of China.
Free Radic Biol Med
January 2025
Neonatal Research Group, Health Research Institute Hospital La Fe (IISLAFE), Avda Fernando Abril Martorell 106, 46026, Valencia, Spain; Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS SAMID) (RD24/0013/0014), Instituto de Salud Carlos III, Madrid, Spain; Division of Neonatology, University & Polytechnic Hospital La Fe, Avda Fernando Abril Martorell 106, 46026, Valencia, Spain. Electronic address:
Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator that is used as a treatment for persistent pulmonary hypertension in neonates (PPHN) with hypoxic respiratory failure. The generation of reactive oxygen and nitrogen species might induce oxidative/nitrosative damage to multiple organs. There is an increasing scientific and clinical interest in the determination of specific biomarkers to measure the degree of oxidative/nitrosative stress in non-invasively collected biofluids.
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