IL-10 and IL-10 receptor defects in humans.

Ann N Y Acad Sci

Institute of Medical Microbiology and Hygiene, University Hospital Freiburg, Germany.

Published: December 2011

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is chronic in nature and is characterized by abdominal pain, diarrhea, bleeding, and malabsorption. It is considered a complex multigenic and multifactorial disorder that results from disturbed interactions between the immune system and commensal bacteria of the gut. Recent work has demonstrated that IBD with an early-onset within the first months of life can be monogenic: mutations in IL-10 or its receptor lead to a loss of IL-10 function and cause severe intractable enterocolitis in infants and small children. Both IL-10 and IL-10 receptor deficiency can be successfully treated by hematopoietic stem cell transplantation.

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2011.06339.xDOI Listing

Publication Analysis

Top Keywords

il-10 receptor
12
il-10 il-10
8
il-10
5
receptor defects
4
defects humans
4
humans inflammatory
4
inflammatory bowel
4
bowel disease
4
disease ibd
4
ibd includes
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!