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A tumor-targeting porphyrin-micelle with enhanced STING agonist delivery and synergistic photo-/immuno- therapy for cancer treatment.
Acta Biomater
December 2024
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China; National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
The activation of STING pathway has emerged as a promising strategy in cancer immunotherapy. However, challenges associated with unfavorable physicochemical properties and potential off-target toxicities have limited the application of STING agonists. Here, we develop an amphiphilic and cationic charged porphyrin-polymer to electrostatically load the STING agonist (MSA-2) within a micellar structure, thereby enhancing carrier compatibility and drug-loading content of MSA-2.
View Article and Find Full Text PDFAdvances in deep learning have significantly aided protein engineering in addressing challenges in industrial production, healthcare, and environmental sustainability. This review frames frequently researched problems in protein understanding and engineering from the perspective of deep learning. It provides a thorough discussion of representation methods for protein sequences and structures, along with general encoding pipelines that support both pre-training and supervised learning tasks.
View Article and Find Full Text PDFUltraNet: Unleashing the Power of Simplicity for Accurate Medical Image Segmentation.
Interdiscip Sci
December 2024
College of Mathematics and Systems Science, Shandong University of Science and Technology, Qingdao, 266590, China.
The imperative development of point-of-care diagnosis for accurate and rapid medical image segmentation, has become increasingly urgent in recent years. Although some pioneering work has applied complex modules to improve segmentation performance, resulting models are often heavy, which is not practical for the modern clinical setting of point-of-care diagnosis. To address these challenges, we propose UltraNet, a state-of-the-art lightweight model that achieves competitive performance in segmenting multiple parts of medical images with the lowest parameters and computational complexity.
View Article and Find Full Text PDFUnleashing nature's defense: potent antimicrobial power of plant extracts against oral pathogens and Streptococcus mutans biofilms.
Front Oral Health
December 2024
Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine University of Zurich, Zurich, Switzerland.
Objectives: The increasing demand for alternatives to antibiotics against resistant bacteria has led to research on natural products. The aim of this study was to analyze the antimicrobial and antibiofilm activity of 16 Mediterranean herb extracts.
Materials And Methods: The extracts were analyzed using High Performance Thin Layer Chromatography.
Highly Efficient Electrode of Dirac Semimetal PtTe for MoS-Based Field Effect Transistors.
ACS Appl Mater Interfaces
December 2024
Beijing Academy of Quantum Information Sciences, Beijing 100193, China.
Two-dimensional van der Waals (vdW) layered materials not only are an intriguing fundamental scientific research platform but also provide various applications to multifunctional quantum devices in the field-effect transistors (FET) thanks to their excellent physical properties. However, a metal-semiconductor (MS) interface with a large Schottky barrier causes serious problems for unleashing their intrinsic potentials toward the advancements in high-performance devices. Here, we show that exfoliated vdW Dirac semimetallic PtTe can be an excellent electrode for electrons in MoS FETs.
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