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Investigating the Role of TRPV4 and GPR35 Interaction in Endothelial Dysfunction in Aging Mice.
Aging Cell
January 2025
Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Endothelial dysfunction, characterized by a decline in endothelial physiological functions, is a significant aspect of cardiovascular aging, contributing notably to arterial stiffness, atherosclerosis, and hypertension. Transient receptor potential channel V4 (TRPV4), a key member of Ca-permeable channels, plays a crucial role in maintaining vascular functions. However, the role and mechanisms of TRPV4 in aging-related endothelial dysfunction remain incompletely understood.
View Article and Find Full Text PDFTargeting ion channels: innovative approaches to combat cancer drug resistance.
Theranostics
January 2025
School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Ion channels, as functional molecules that regulate the flow of ions across cell membranes, have emerged as a promising target in cancer therapy due to their pivotal roles in cell proliferation, metastasis, apoptosis, drug resistance, and so on. Recently, increasing evidence suggests that dysregulation of ion channels is a common characteristic of cancer cells, contributing to their survival and the resistance to conventional therapies. For example, the aberrant expression of sodium (Na) and potassium ion (K) channels is significantly correlated with the sensitivity of chemotherapy drugs.
View Article and Find Full Text PDFThe modulation of calcium and chloride channels induces cardiomyocytes from human pluripotent stem cells.
Int J Biol Sci
January 2025
Faculty of Health Sciences, University of Macau, Taipa, Macau.
Ion channels play a crucial role in cardiac functions, and their activities exhibit dynamic changes during heart development. However, the precise function of ion channels in human heart development remains elusive. In this study, we utilized human embryonic stem cells (hESCs) as a model to mimic the process of human embryonic heart development.
View Article and Find Full Text PDFMineral Scaling in 3D Interfacial Solar Evaporators─A Challenge for Brine Treatment and Lithium Recovery.
Environ Sci Technol
January 2025
Department of Civil and Environmental Engineering, University of California, Berkeley, Berkeley, California 94720, United States.
In this work, we analyzed the effects of mineral scaling on the performance of a 3D interfacial solar evaporator, with a focus on the cations relevant to lithium recovery from brackish water. The field has been rapidly moving toward resource recovery applications from brines with higher cation concentrations. However, the potential complications caused by common minerals in these brines other than NaCl have been largely overlooked.
View Article and Find Full Text PDFVSMC-specific TRPC1 deletion attenuates angiotensin II-induced hypertension and cardiovascular remodeling.
J Mol Med (Berl)
January 2025
Wuxi School of Medicine, Jiangnan University, Jiangsu Province, 1800 Lihu Rd, Wuxi, 214122, China.
Transient receptor potential canonical 1 (TRPC1) channel, a Ca-permeable ion channel widely expressed in vasculature, has been reported to be involved in various cardiovascular disorders. However, the pathophysiological function of vascular smooth muscle cell (VSMC)-derived TRPC1 in hypertension and hypertensive cardiovascular remodeling remains to be defined. In this study, we found increased TRPC1 expression in both angiotensin II (AngII)-treated VSMCs and aortas from AngII-infused mice.
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