AI Article Synopsis
- The study investigated the effects of Sigma Anti-bonding Molecule Calcium Carbonate (SAC) on osteoporosis caused by ovariectomy in rats.
- Three groups of ovariectomized rats were analyzed: a control group (sham), an ovariectomized group (OVX), and a treated group receiving SAC in their drinking water for 12 weeks.
- Results showed that SAC treatment helped restore levels of key hormones and minerals associated with bone health, significantly improving bone strength and mineral density despite not affecting reproductive organ weights.
Article Abstract
This study was conducted to evaluate the effect of Sigma Anti-bonding Molecule Calcium Carbonate (SAC) as therapy for ovariectomy-induced osteoporosis in rats. Three weeks after surgery, fifteen ovariectomized Sprague-Dawley rats were divided randomly into 3 groups: sham-operated group (sham), ovariectomized group (OVX) and SAC-treatment group (OVX+SAC). The OVX+SAC group was given drinking water containing 0.0012% SAC for 12 weeks. Bone breaking force and mineralization as well as blood parameters related to the bone metabolism were analyzed. In OVX animals, blood concentration of 17β-estradiol decreased significantly, while osteocalcin and type I collagen C-terminal telopeptides (CTx) increased. Breaking force, bone mineral density (BMD), calcium and phosphorus in femurs, as well as uterine and vaginal weights, decreased significantly following OVX. However, SAC treatment (0.0012% in drinking water) not only remarkably restored the decreased 17β-estradiol and increased osteocalcin and CTx concentrations, but also recovered decreased femoral breaking force, BMD, calcium and phosphorus, although it did not reversed reproductive organ weights. It is suggested that SAC effectively improve bone density by preventing bone turnover mediated osteocalcin, CTx and minerals, and that it could be a potential candidate for therapy or prevention of postmenopausal osteoporosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251760 | PMC |
| http://dx.doi.org/10.5625/lar.2011.27.4.301 | DOI Listing |
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