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Natural products as kinase inhibitors. | LitMetric

Natural products as kinase inhibitors.

Nat Prod Rep

High Magnetic Field laboratory, Chinese Academy of Sciences, P.O. Box 1110, Hefei, Anhui 230031, PR China.

Published: March 2012

AI Article Synopsis

Article Abstract

Natural products have been widely used to dissect the basic mechanisms of fundamental life science and as clinical therapeutics. Recently, there has been significant interest in discovering new chemical pharmacophores in natural products to fulfil the vast demand for novel kinase inhibitors and address critical unmet medical needs with respect to signal transduction pathways. In this review, we summarize the history of several different classes of natural product-derived kinase inhibitors, discuss their kinome-wide target profiles and examine their structural binding modes based on available 3D X-ray structures. In particular, their origin, target activity, selectivity, scope and potential therapeutic development are highlighted against the backdrop of medicinal chemistry.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c2np00097kDOI Listing

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