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Latent tuberculosis prevalence in healthcare workers in Laos: a cross-sectional study.
Trop Med Health
January 2025
LaoLuxLab/Vaccine Preventable Diseases Laboratory, Institut Pasteur du Laos, Vientiane, Laos.
Background: Individuals with latent tuberculosis infection (LTBI) have a high risk of active infection, morbidity and mortality. Healthcare workers are a group who have increased risk of infection and onward transmission to their patients and other susceptible individuals; however, LTBI is often undiagnosed, and individuals are asymptomatic. Interferon gamma release assays (IGRA) can detect evidence of TB infection in otherwise asymptomatic individuals and are a good indication of LTBI.
View Article and Find Full Text PDF4D structural biology-The 9 Murnau Conference on structural biology.
Structure
January 2025
Biochemistry Center Heidelberg, Heidelberg University, 69120 Heidelberg, Germany. Electronic address:
The data presented at the 9 International Murnau Conference on September 18-21, 2024, the largest recurring structural biology meeting in Central Europe, illustrated the thriving state of the structural biology community. This is largely attributed to the ground-breaking developments over the last decade, which were intensely discussed during the meeting.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Washington University School of Medicine in St Louis, St. Louis, MO, USA.
As part of the goal of the ADSP to develop effect therapeutic for AD, it has become imperative to develop therapeutic targets for APOE4. The Apolipoprotein E4 gene (APOE4) strongest genetic risk factor for AD and is present in 64% of sporadic, late-onset AD, with a recent prevalence estimate of 245 million carriers worldwide. A key question is whether APOE4 is a toxic or gain of function allele or alternatively if its effect is due to a loss or partial loss of function.
View Article and Find Full Text PDFSport-specific differences in ACL injury, treatment and return to sports: Basketball.
Knee Surg Sports Traumatol Arthrosc
January 2025
Division of Neurosciences and Musculoskeletal Diseases, Department of Orthopaedic Surgery, Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg.
Basketball is an intense, fast-paced game that is physically, highly demanding. Certain aspects of the game, such as the quick pivoting and cutting movements, predispose the players to serious knee injuries, including anterior cruciate ligament (ACL) tears. While an ACL tear can be a devastating condition for players, multidisciplinary management of the injury can provide the players with a reasonable chance to return to play at the pre-injury level.
View Article and Find Full Text PDFCurrent Use of Physiologically Based Pharmacokinetic modeling in New Medicinal Product Approvals at EMA.
Clin Pharmacol Ther
January 2025
European Medicines Agency, Amsterdam, The Netherlands.
Physiologically Based Pharmacokinetic (PBPK) Models are routinely used in drug development and therefore appear frequently in marketing authorization applications (MAAs) to the European Medicines Agency (EMA). For a model to be a key source of evidence for a regulatory decision, it must be considered qualified for the intended use. Advice on the data expected to allow qualification of a PBPK model or platform is provided in the EMA Guideline on the reporting of PBPK modeling and simulation.
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