The neural crest is a multipotent and migratory cell type that forms transiently in the developing vertebrate embryo. These cells emerge from the central nervous system, migrate extensively and give rise to diverse cell lineages including melanocytes, craniofacial cartilage and bone, peripheral and enteric neurons and glia, and smooth muscle. A vertebrate innovation, the gene regulatory network underlying neural crest formation appears to be highly conserved, even to the base of vertebrates. Here, we present an overview of important concepts in the neural crest field dating from its discovery 150 years ago to open questions that will motivate future research.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351559 | PMC |
| http://dx.doi.org/10.1016/j.ydbio.2011.12.042 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Polarity and migration of cranial and cardiac neural crest cells: underlying molecular mechanisms and disease implications.
Front Cell Dev Biol
January 2025
Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile.
The Neural Crest cells are multipotent progenitor cells formed at the neural plate border that differentiate and give rise to a wide range of cell types and organs. Directional migration of NC cells and their correct positioning at target sites are essential during embryonic development, and defects in these processes results in congenital diseases. The NC migration begins with the epithelial-mesenchymal transition and extracellular matrix remodeling.
View Article and Find Full Text PDFEpithelial-Mesenchymal Transition Functions as a Driver for the Direct Conversion of Somatic Cells.
Stem Cells Dev
January 2025
Department of Molecular Design and Synthesis, Functional Biology Division, Gifu University Graduate School of Medicine, Gifu, Japan.
Direct conversion is an innovative new technology that involves the conversion of somatic cells to target cells without passing through a pluripotent state. Forced expression alone or in combination with transcription factors (TFs), which are critical for the generation of target cells, is important for successful direct conversion. However, most somatic cells are unable to directly convert into target cells even with forced expression.
View Article and Find Full Text PDFA Cadaveric Case Report of Bilateral Accessory Anterior Bellies of the Digastric Muscles.
Cureus
December 2024
Department of Anatomical Sciences, William Carey University College of Osteopathic Medicine, Hattiesburg, USA.
The digastric muscle is a suprahyoid muscle that is composed of an anterior belly and a posterior belly, which originate from the first and second pharyngeal arches, respectively, and they are innervated by the nerves of these arches. The digastric muscles are involved in the elevation of the hyoid bone and depression of the mandible during mastication, speech, and swallowing. In this report, we present the rare case of bilateral accessory anterior belly of the digastric muscles (ABDMs) that originated from the digastric fossa, medial to the anterior bellies.
View Article and Find Full Text PDFBackground: Hirschsprung disease (HSCR) is a rare neurodevelopmental disorder caused by disrupted migration and proliferation of enteric neural crest cells during enteric nervous system development. Genetic studies suggest a complex etiology involving both rare and common variants, but the contribution of ultra-rare pathogenic variants (PAs) remains poorly understood.
Methods: We perform whole-exome sequencing (WES) on 301 HSCR probands and 109 family trios, employing advanced statistical methods and gene prioritization strategies to identify genes carrying and ultra-rare coding pathogenic variants.
Jansen metaphyseal chondrodysplasia: analysis of craniofacial manifestations.
JBMR Plus
February 2025
Radiology and Imaging Sciences, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD 20892, United States.
Jansen metaphyseal chondrodysplasia (JMC) is an ultra-rare disorder caused by constitutive activation of parathyroid hormone type 1 receptor (PTH1R). We sought to characterize the craniofacial phenotype of patients with the disease. Six patients with genetically confirmed JMC underwent comprehensive craniofacial phenotyping revealing a distinct facial appearance that prompted a cephalometric analysis demonstrating a pattern of mandibular retrognathia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!