The effects of endothelin on systemic hemodynamics and renal functions were investigated in anesthetized dogs. Infusion of endothelin at a dose of 1 ng/kg/min decreased renal blood flow and increased renal vascular resistance and filtration fraction. Endothelin at doses higher than 10 ng/kg/min significantly decreased cardiac output, glomerular filtration rate, renal plasma flow, urine volume, and urinary sodium excretion. Mean arterial pressure showed a transient decrease at doses higher than 50 ng/kg/min. These results showed that endothelin in systemic administration has effects on renal functions as well as on systemic hemodynamics.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ajh/3.10.792 | DOI Listing |
Publication Analysis
Top Keywords
effects endothelin
8
anesthetized dogs
8
endothelin systemic
8
systemic hemodynamics
8
renal functions
8
ng/kg/min decreased
8
doses higher
8
higher ng/kg/min
8
renal
6
endothelin
5
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!