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Prevalence of Common Child Mental Health Disorders Using Administrative Health Data and Parent Report in a Prospective Community-Based Cohort from Alberta, Canada: Prévalence des troubles communs de santé mentale de l'enfant à l'aide des données de santé administratives et des rapports des parents dans une cohorte prospective communautaire d'Alberta, Canada.
Can J Psychiatry
October 2024
Department of Psychology, University of Calgary, Calgary, Alberta, Canada.
Objective: Knowing the prevalence of mental health difficulties in young children is critical for early identification and intervention. In the current study, we examine the agreement among three different data sources estimating the prevalence of diagnoses for attention deficit hyperactivity disorder (ADHD) and emotional disorders (i.e.
View Article and Find Full Text PDFA randomized controlled trial of recovery management checkups for primary care patients: Twelve-month results.
Alcohol Clin Exp Res (Hoboken)
October 2023
Chestnut Health Systems, Normal, Illinois, USA.
Background: Primary care settings like federally qualified health centers (FQHC) are optimal locations to identify individuals with substance use disorders (SUD) and link them to SUD treatment, yet successful linkage has proven difficult. Recovery management checkups for primary care (RMC-PC) is a promising method for increasing linkage to care, engagement in treatment, and reducing substance use.
Methods: Participants (n = 266) who received screening, brief intervention, and referral to treatment (SBIRT) at four FQHC sites and needed SUD treatment were randomized to receive SBIRT only or SBIRT+RMC-PC.
Changes in Depressive Symptoms of Korean American Dementia Caregivers After Attending the Savvy Caregiver Program: Preliminary Findings with a Pilot Sample.
Clin Gerontol
October 2024
School of Nursing, University of Texas at Austin, Austin, USA.
Article Synopsis
- Language accommodation is essential for providing effective interventions to ethnic minorities with limited English, exemplified by adapting the Savvy Caregiver Program for Korean American dementia caregivers.
- The study involved two groups of 13 Korean American caregivers, where their depressive symptoms were evaluated before, right after, and six months after participating in the program led by Korean-speaking trainers.
- Results showed a significant decrease in depressive symptoms post-intervention that continued at the six-month mark, indicating that delivering programs in participants' native languages can enhance therapeutic benefits for linguistic minorities.
Single-agent belantamab mafodotin in patients with relapsed/refractory multiple myeloma: Final analysis of the DREAMM-2 trial.
Cancer
December 2023
Winship Cancer Institute, Emory University Hospital, Atlanta, Georgia, USA.
Article Synopsis
- Belantamab mafodotin (belamaf) is a new treatment for patients with relapsed/refractory multiple myeloma (RRMM), targeting myeloma cells and enhancing immune response.
- The DREAMM-2 trial tested belamaf in heavily pretreated patients, revealing an overall response rate (ORR) of 32% to 35%, with median progression-free survival (PFS) of 2.8 to 3.9 months and overall survival (OS) of 14 to 15.3 months.
- The treatment demonstrated a manageable safety profile, with common side effects including keratopathy and thrombocytopenia, while also maintaining or
Oxidised IL-33 drives COPD epithelial pathogenesis ST2-independent RAGE/EGFR signalling complex.
Eur Respir J
September 2023
Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK
Background: Epithelial damage, repair and remodelling are critical features of chronic airway diseases including chronic obstructive pulmonary disease (COPD). Interleukin (IL)-33 released from damaged airway epithelia causes inflammation its receptor, serum stimulation-2 (ST2). Oxidation of IL-33 to a non-ST2-binding form (IL-33) is thought to limit its activity.
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