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Patient-derived olfactory mucosa cells but not lung or skin fibroblasts mediate axonal regeneration of retinal ganglion neurons. | LitMetric

AI Article Synopsis

  • Human olfactory mucosa derived cells (OMC) are used for CNS repair, but their identity and neuroregenerative ability in lab cultures are not fully understood.
  • The study compared OMC with other cell types, such as olfactory bulb ensheathing glia and fibroblasts, finding substantial overlap in their identifying markers, making them hard to differentiate.
  • In experiments with rat retinal ganglion neurons, OMC and olfactory bulb ensheathing glia showed significantly greater axonal regeneration compared to fibroblasts, highlighting the unique neuroregenerative potential of cells from the human olfactory system.

Article Abstract

Although human olfactory mucosa derived cells (OMC) have been used in animal models and clinical trials with CNS repair purposes, the exact identity of these cells in culture with respect to their tissue of origin is not fully understood and their neuroregenerative capacity in vitro has not yet been demonstrated. In this study we have compared human OMC with human ensheathing glia from olfactory bulb (OB) and human fibroblasts from skin and lung. Our results indicate that these different cultured cell types exhibit considerable overlap of antigenic markers such that it is presently not possible to distinguish them immunocytochemically. However, in rat retinal ganglion neuron coculture assays the axonal regenerative activity of OMC and OB ensheathing glia was dramatically higher than that exhibited by all fibroblast samples, confirming neuroregenerative activity as a unique property shared by cultured cells derived from the human olfactory system.

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Source
http://dx.doi.org/10.1016/j.neulet.2011.12.037DOI Listing

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