AI Article Synopsis
- - T-cell deficiency is common after allogeneic stem cell transplantation (ASCT), and its levels can significantly affect patient outcomes.
- - A study of 210 patients found that using bone marrow grafts leads to higher levels of T-cell receptor excision circles (TRECs) after 6 months, while anti-thymocyte globulin treatment results in lower TREC levels within the first 6 months.
- - Higher TREC levels at 3 months post-transplantation are associated with better overall survival rates (80% vs. 56%) and reduced transplantation-related mortality (7% vs. 21%), suggesting the importance of monitoring TREC levels in post-ASCT care.
Article Abstract
T-cell deficiency after allogeneic stem cell transplantation (ASCT) is common and has major impact on clinical outcome. In this retrospective study 210 patients were analyzed with regards to levels of T-cell receptor excision circles (TRECs) during the first 24 months after transplantation. We could for the first time show a significant correlation between the use of bone marrow grafts and higher TREC levels >6 months post-ASCT (p<0.001). Treatment with anti-thymocyte globulin was correlated with lower TREC levels ≤6 months post-ASCT (p<0.001). Patients with TREC levels above median at 3 months had a superior overall survival, 80% vs. 56% (p=0.002), and lower transplantation-related mortality, 7% vs. 21% (p=0.01). We conclude that graft source and conditioning regimen may have a significant effect on T-cell reconstitution after ASCT and can thus affect outcome. These results strongly support the use of TREC measurement as part of the standard repertoire of immunological monitoring after ASCT.
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| http://dx.doi.org/10.1016/j.clim.2011.12.001 | DOI Listing |
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