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Thermal ocular burns and evaluation of associated limbal stem cell deficiency in the light of global consensus.
Int Ophthalmol
January 2025
Department of Ophthalmology, Ege University Faculty of Medicine, 35100, Bornova, Izmir, Türkiye.
Purpose: The aim of the present study is to examine the demographic data and clinical features of ocular surface injuries due to thermal burns and to evaluate LSCD in the light of global consensus.
Methods: Thirty-three eyes of 20 cases with ocular surface injury due to thermal burn who attended to the clinic between 2012 and 2023 were included in the study. LSCD severity was staged according to the global consensus which was published in 2019.
Unveiling the epidemiology and community perspectives on bovine brucellosis in North Shewa, Central Highlands of Ethiopia.
Sci Rep
January 2025
College of Veterinary Medicine and Agriculture, Addis Ababa University, P. O. Box 34, Bishoftu, Ethiopia.
Brucellosis is a bacterial disease of many domestic and wild animals with great economic and public health importance. Although it has a major constraint in dairy production, comprehensive information regarding the epidemiology of brucellosis in dairy herds is limited. Besides, evaluating the dairy farmers' knowledge, attitude, and practice (KAP) regarding brucellosis is crucial for generating information that can enhance control programs and public health interventions.
View Article and Find Full Text PDFA prospective observational multicenter cohort study of maternal serum sFlt-1 and PlGF concentration in prediction of adverse neonatal outcomes in small for gestational age newborns delivered ≥34 weeks of gestation.
J Matern Fetal Neonatal Med
December 2025
Department of Obstetrics, Perinatology and Neonatology, Center of Postgraduate Medical Education, Warsaw, Poland.
Introduction: Small-for-gestational age (SGA) newborns are at increased risk of adverse neonatal outcomes and the risk is related to the etiology of growth restriction: highest in placental insufficiency, lowest in constitutional SGA. The aim of this study was to investigate if placental growth factor (PlGF), soluble fms-like tyrosine kinase-1(sFlt-1) or sFlt-1/PlGF ratio are efficient in prediction of adverse neonatal outcomes in SGA newborns delivered ≥34 weeks of gestation.
Methods: A prospective observational multicenter cohort study was performed.
The neuroprotective effect of human umbilical cord MSCs-derived secretome against α-synuclein aggregates on the blood-brain barrier.
Int J Biol Macromol
January 2025
Department of Bioprocess Engineering, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran. Electronic address:
The blood-brain barrier (BBB) is a specialized network that maintains central nervous system homeostasis. Disruption of the BBB can lead to neuronal damage and contribute to neurodegenerative diseases like Parkinson's disease (PD), characterized by alpha-synuclein (αSN) aggregation, which forms intracellular inclusions. Mesenchymal stem cells (MSCs) have shown promise in alleviating the severity of neurological diseases through their paracrine secretions.
View Article and Find Full Text PDFFetal fibroblast heterogeneity defines dermal architecture during human embryonic skin development.
J Invest Dermatol
January 2025
Centre for Gene Therapy and Regenerative Medicine, King's College London, Guy's Hospital, Great Maze Pond, London, UK; Directors' Unit, EMBL, Meyerhofstr. 1, 69117 Heidelberg, Germany. Electronic address: https://twitter.com/fionamarywatt.
To investigate heterogeneity of fibroblasts in human fetal skin, we analysed published single-cell RNA sequencing data (8 and 16 post conception weeks (PCW)) and performed single-molecule fluorescence in situ hybridisation to map their spatial distribution and predicted dynamic interactions. Clustering revealed 8 fibroblast populations with developmental stage-specific abundance changes. Proliferative cells (MKI67+) were present at all stages.
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