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Chronic coronary syndromes without standard modifiable cardiovascular risk factors and outcomes: the CLARIFY registry.
Eur Heart J
July 2024
Cardiology Department, AP-HP, Hôpital Bichat, 46 Rue Henri Huchard, 75018 Paris, France.
Article Synopsis
- Patients without standard modifiable cardiovascular risk factors (SMuRFs) experience lower in-hospital mortality after a first heart attack compared to those with risk factors, but their long-term outcomes are less understood, especially in women.
- This study analyzed a large cohort of patients with stable coronary artery disease, comparing outcomes based on the presence or absence of SMuRFs over a 5-year period.
- Results showed that SMuRF-less patients had a significantly lower rate of cardiovascular death and non-fatal heart attacks, indicating that having fewer risk factors correlates with better long-term heart health outcomes.
Prevention of Blood Incompatibility Related Hemagglutination: Blocking of Antigen A on Red Blood Cells Using Designed Recombinant Anti-A scFv.
Antibodies (Basel)
August 2024
Atta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, H-12 Sector, Islamabad 44000, Pakistan.
Critical blood shortages plague healthcare systems, particularly in lower-income and middle-income countries. This affects patients requiring regular transfusions and creates challenges during emergencies where universal blood is vital. To address these shortages and support blood banks during emergencies, this study reports a method for increasing the compatibility of blood group A red blood cells (RBCs) by blocking surface antigen-A using anti-A single chain fragment variable (scFv).
View Article and Find Full Text PDFPrevalence, predictors, and in-hospital outcomes of ST-elevation myocardial infarction among young adults without traditional cardiovascular risk factors in the United States.
Am Heart J Plus
July 2024
Division of Cardiovascular Medicine, Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
Article Synopsis
- Young patients with ST-elevation myocardial infarction (STEMI) who lack standard cardiovascular risk factors (like high blood pressure or diabetes) experience worse outcomes compared to those with these risk factors.
- In a study involving nearly 42,000 patients, those without any traditional risk factors were more likely to be female and have congestive heart failure, but less likely to be obese.
- The findings revealed that these SMuRF-less patients faced significantly higher rates of in-hospital mortality and other serious complications, highlighting the need for further research on non-traditional risk factors in heart issues.
Decreased exercise-induced natural killer cell redistribution in multiple sclerosis.
Mult Scler Relat Disord
July 2024
Neurology Department, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. Electronic address:
Background: Exercise may have beneficial effects in MS, remaining controversial its possible disease-modifying effects and which mechanisms might be involved. We evaluated whether exercise-induced lymphocyte redistribution differ in MS patients as compared to controls.
Methods: Exercise was assessed in 12 relapsing-remitting MS patients and 11 controls in a cycle ergometer, obtaining blood samples before exercise, at maximal exercise capacity (T1), and after resting (T2).
Our experience and modification of the Antia-Buch flap for pinna reconstruction.
J Plast Reconstr Aesthet Surg
March 2023
Department of Otorhinolaryngology, Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Trust, United Kingdom.
Objective: The Antia-Buch flap technique is used for the reconstruction of pinna helical defects. We present our modification of this flap to reconstruct large defects (greater than 20 mm) with good outcomes.
Methods: A retrospective review was conducted on all modified Antia-Buch flaps performed in a single unit from January 2011 to April 2019.
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