AI Article Synopsis
- The study explores the effects of chronic uranium exposure from drinking water on the kidney microdistribution in rats, using secondary ion mass spectrometry (SIMS) to analyze uranium levels over varying exposure durations.
- After 6 to 12 months of exposure, uranium mainly accumulates in the proximal tubules, but after 18 months, it spreads throughout all nephron segments.
- The research highlights SIMS as a valuable method for detecting trace elements and creating detailed elemental maps at the micrometer level.
Article Abstract
For a few years, the biological effects on ecosystems and the public of the bioaccumulation of radionuclides in situations of chronic exposures have been studied. This work, in keeping with the ENVIRHOM French research program, presents the uranium microdistribution by secondary ion mass spectrometry (SIMS) technique in the renal cortex of rats following chronic exposure to this low level element in the drinking water (40 mg/L) as a function to exposure duration (6, 9, 12, and 18 months). The SIMS mass spectra and 238U+ ion images produced with a SIMS CAMECA 4F-E7 show the kinetic of uranium accumulation in the different structures of the kidney. For the rats contaminated up to 12 months, the radioelement is mainly fixed in the proximal tubules; then after 18 exposure months, uranium is detected in all the segments of the nephron. This work has also shown that ion microscopy is an analytical method to detect trace elements and give elemental cartography at the micrometer scale.
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| http://dx.doi.org/10.1017/S1431927611012384 | DOI Listing |
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