AI Article Synopsis
- The study investigates the levels of adiponectin and leptin in children and adolescents with extreme obesity compared to those with normal weight, overweight, and regular obesity.
- Leptin levels significantly increased across the BMI groups, with extreme obese participants showing the highest levels, indicating a potential risk for future weight gain.
- Adiponectin levels were notably lower in extreme obese youth compared to those with normal weight, but did not differ significantly among the other obesity categories.
Article Abstract
Background: Adiponectin and leptin, adipokines associated with metabolic syndrome, type 2 diabetes, and cardiovascular disease, have not been well characterized in extreme pediatric obesity. Therefore, levels were compared in youth that were extremely obese (EO) to normal weight (NW), overweight (OW), and obese (OB) youth.
Methods: Leptin, adiponectin, body mass index (BMI), blood pressure, fasting glucose, insulin, and lipids were obtained in 277 children and adolescents (age 13.4±2.6 years; 152 boys). Participants were classified into four BMI groups (NW, OW, OB, EO). Variables were compared across groups using analysis of covariance (ANCOVA) adjusted for gender, age, and race.
Results: Risk factors generally worsened across BMI groups. EO had significantly higher levels of leptin than OB (P<0.0001), OW (P<0.0001), and NW (P<0.0001). Leptin was higher in OB compared to OW (P<0.005) and NW (P<0.0001) and higher in OW compared to NW (P<0.0001). Adiponectin levels in EO did not significantly differ from OB or OW but were significantly lower than NW (P<0.0001). Adiponectin was not significantly different among the OB, OW, and NW groups.
Conclusions: Leptin was markedly elevated in EO children and adolescents, suggesting that this subset of obese youth may be at particularly high risk of future weight gain and potentially reduced response to weight-loss interventions.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339383 | PMC |
| http://dx.doi.org/10.1089/met.2011.0086 | DOI Listing |
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