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| http://dx.doi.org/10.1111/j.1365-2125.1976.tb04891.x | DOI Listing |
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A prospective study of acute propranolol overdose defining dose thresholds of severe toxicity (ATOM - 9).
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January 2025
Clinical Toxicology Research Group, University of Newcastle, Newcastle, Australia.
Introduction: Propranolol is a beta-adrenoceptor blocking drug with sodium channel-blocking properties that can cause life-threatening toxicity in overdose. Limited research defines dose thresholds of toxicity. We aimed to investigate propranolol overdose and dose thresholds for severe toxicity.
View Article and Find Full Text PDFDrugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion therapy (MET).
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Hannover Medical School, Division of Surgery, Department of Urology & Urological Oncology, Hannover, Germany.
Purpose: Urolithiasis and symptomatic ureterolithiasis represent diseases known to be on the increase in most westernized countries. The present article aims to give an overview on some drug principles assumed to target signalling systems involved in modulating ureter smooth muscle contractility and to present background to their potential use or prospects in ureter stone disease.
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Automaticity of the Pulmonary Vein Myocardium and the Effect of Class I Antiarrhythmic Drugs.
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Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama Funabashi, Chiba 274-8510, Japan.
The pulmonary vein wall contains a myocardial layer whose ectopic automaticity is the major cause of atrial fibrillation. This review summarizes the results obtained in isolated pulmonary vein myocardium from small experimental animals, focusing on the studies with the guinea pig. The diversity in the action potential waveform reflects the difference in the repolarizing potassium channel currents involved.
View Article and Find Full Text PDFNyctohemeral effects of topical beta-adrenoceptor blocking agents measured with an intraocular telemetry sensor.
Br J Ophthalmol
November 2024
Hamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California, La Jolla, California, USA.
Objective: To evaluate nyctohemeral effects of topical beta-adrenoceptor blocking agents and their fixed combinations on intraocular pressure (IOP) in patients with primary open-angle glaucoma implanted with an ocular telemetry sensor.
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Development of new K2.1 channel openers from propafenone analogues.
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Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Article Synopsis
- Reduced functioning of the K2.1 potassium channel is linked to conditions like heart failure and Andersen-Tawil Syndrome, making it crucial to find treatments that specifically target this channel, as current therapies do not.
- Research analyzed the effects of propafenone and its analogues on the K2.1 channel using techniques like patch-clamp electrophysiology and western blot analysis, highlighting the potential of these compounds to improve potassium current.
- Notably, the analogue GPV0057 increased the potassium current without blocking it at low concentrations, suggesting it could be a viable treatment option for diseases related to K2.1 deficiency.
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