Perception of temperature is an important brain function for organisms to survive. Evidence suggests that temperature preference behavior (TPB) in Drosophila melanogaster, one of poikilothermal animals, is regulated by cAMP-dependent protein kinase (PKA) signaling in mushroom bodies of the brain. However, downstream targets for the PKA signaling in this behavior have not been identified. From a genome-wide search for the genes regulated by PKA activity in the mushroom bodies, we identified the cyp6a17 Cytochrome P450 gene as a new target for PKA. Our detailed analysis of mutants by genetic, molecular and behavioral assays shows that cyp6a17 is essential for temperature preference behavior. cyp6a17 expression is enriched in the mushroom bodies of the adult brain. Tissue-specific knockdown and rescue experiments demonstrate that cyp6a17 is required in the mushroom bodies for normal temperature preference behavior. This is the first study, to our knowledge, to show PKA-dependent expression of a cytochrome P450 gene in the mushroom bodies and its role as a key factor for temperature preference behavior. Taken together, this study reveals a new PKA-Cytochrome P450 pathway that regulates the temperature preference behavior.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247289 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029800 | PLOS |
Ecology
January 2025
Department of Biological Sciences, Brock University, St. Catharines, Ontario, Canada.
Optimal nest site selection is crucial in animals whose offspring are completely dependent on the shelter of a nest. Parental decisions influencing nest thermal conditions are particularly important because temperature strongly influences juvenile activity, metabolism, growth, developmental rate, survival, and adult body size. In small ectotherms such as bees, maternal decisions to nest in sun-exposed or shady sites can lead to marked differences in thermal microenvironments inside nests.
View Article and Find Full Text PDFPhys Chem Chem Phys
January 2025
Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang 621900, China.
Energetic materials often possess different polymorphs that exhibit distinguishable performances. As a typical energetic material, hexanitrohexaazaisowurtzitane (CL-20 or HNIW) is one of the most powerful explosives nowadays. Phase transition of CL-20 induced by ubiquitous water vapor leading to an increase in sensitivity and a decrease in energy level is a key bottleneck that limits the widespread application of CL-20-based explosives.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506, United States.
Metal flux methods are excellent for synthesizing high-quality hexagonal boron nitride (hBN) crystals, but the atomic mechanisms of hBN nucleation and growth in these systems are poorly understood and difficult to probe experimentally. Here, we harness classical reactive molecular dynamics (ReaxFF) to unravel the mechanisms of hBN synthesis from liquid nickel solvent over time scales up to 30 ns. These simulations mimic experimental conditions by including relatively large liquid nickel slabs containing dissolved boron and a molecular nitrogen gas phase.
View Article and Find Full Text PDFCarbohydr Polym
March 2025
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China; Quzhou Institute for Innovation in Resource Chemical Engineering, Quzhou 324000, China. Electronic address:
Hermetia illucens, with a short growth cycle, is promising as a valuable source of chitin. However, the optimal method for extracting chitin from this insect and its application for hemostasis has not been addressed. This work employed an environmentally friendly choline chloride-lactic acid deep eutectic solvent technology to extract chitin effectively from the Hermetia illucens pupae shells, realizing one-step removal of inorganic salts and proteins.
View Article and Find Full Text PDFJ Phys Condens Matter
January 2025
Institute of Inorganic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany.
The design of solid-state materials requests a thorough understanding of the structural preferences among plausible structure models. Since the bond energy contributes to the formation energy of a given structure model, it also is decisive to determine the nature of chemical bonding for a given material. In this context, we were motivated to explore the correlation between chemical bonding and structural distortions within the low-dimensional tellurium fragments in TbCuTe.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!