AI Article Synopsis
- Momilactone B (MB) is a natural compound found in rice bran that can reduce melanin production in skin cells (B16 melanocytes) and inhibit the enzyme tyrosinase.
- Transcriptome analysis revealed that MB alters genes related to the protein kinase A (PKA) signaling pathway, leading to decreased levels of key proteins involved in melanin production.
- Overall, MB demonstrates anti-melanogenic properties by suppressing tyrosinase activity and inhibiting PKA signaling, which lowers the expression of genes necessary for melanin production.
Article Abstract
Momilactone B (MB) is a terpenoid phytoalexin present in rice bran that exhibits several biological activities. MB reduced the melanin content in B16 melanocytes melanin content and inhibited tyrosinase activities. Using transcriptome analysis, the genes involved in protein kinase A (PKA) signaling were found to be markedly altered. B16 cells stimulated with MB had decreased concentrations of cAMP protein kinase A activity, and cAMP-response element-binding protein which is a key transcription factor for microphthalmia-associated transcription factor (MITF) expression. Accordingly, the expression of MITF and its target genes, which are essential for melanogenesis, were reduced. MB thus exhibits anti-melanogenic effects by repressing tyrosinase enzyme activity and inhibiting the PKA signaling pathway which, in turn, decreases melanogenic gene expression.
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| http://dx.doi.org/10.1007/s10529-011-0838-7 | DOI Listing |
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