A highly efficient method is reported for the asymmetric ring opening of oxabicyclic alkenes with organolithium reagents. Using a copper/chiral phosphoramidite complex together with a Lewis acid (BF(3)·OEt(2)), full selectivity for the anti isomer and excellent enantioselectivities were obtained for the ring opened products.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c2cc16855c | DOI Listing |
Publication Analysis
Top Keywords
asymmetric ring
8
ring opening
8
opening oxabicyclic
8
oxabicyclic alkenes
8
alkenes organolithium
8
organolithium reagents
8
copper-catalyzed asymmetric
4
reagents highly
4
highly efficient
4
efficient method
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!