Eighteen new limonoids, chubularisins A-R (1-18), along with eleven known analogues, were isolated from the stem bark of Chukrasia tabularis. The structures of 1-18 were elucidated on the basis of spectroscopic data and chemical evidence. Compound 1 represented the first example of 8,9,12-orthoester of phragmalin limonoids. Interestingly, compounds 4, 8, and 22 exhibited potent and selective inhibition against the delayed rectifier (I(K)) K(+) current with IC(50) values of 0.61, 2.03, and 2.15 μM, respectively.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c1ob06666h | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
limonoid plays anti-inflammatory role by regulating NF-B signaling pathway in lipopolysaccharide-induced macrophages.
Food Nutr Res
July 2023
Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Department of Pharmacy, Fujian Medical University, Fuzhou, China.
Background: a well-known tropical tree native to southeastern China, has anti-inflammatory and antioxidant activities, and contains large amounts of limonoids and triterpenoids.
Objective: The aim of this study was to investigate the potential anti-inflammatory activity of limonoids from on lipopolysaccharide (LPS)-mediated RAW264.7 cells.
Phragmalin-Type Limonoids from the Fruits of and Their Anti-Inflammatory Activity.
Molecules
June 2023
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Phytochemical investigation on the fruits of led to the isolation of five new phragmalin-type limonoids (-) and four known ones (-). The structures of the new compounds -, named chuktabamalins A-E, were elucidated via spectroscopic techniques (HRESIMS, 1D and 2D NMR) and were comparable with the literature data of known compounds. In addition, new compounds were evaluated for in vitro anti-inflammatory activity.
View Article and Find Full Text PDFIntegrated pest management of Hypsipyla robusta shoot-tip borer (Lepidoptera: Pyralidae) in Chukrasia tabularis (Sapindales: Meliaceae).
J Econ Entomol
April 2023
Forest Protection Research Centre, Vietnamese Academy of Forest Sciences, Bac Tu Liem, Hanoi 11910, Vietnam.
Chukrasia tabularis A. Juss produces a valuable timber but plantations are susceptible to attack by the shoot-tip borer Hypsipyla robusta Moore. An integrated pest management (IPM) approach is desirable to limit the extent of damage.
View Article and Find Full Text PDFEvaluation of air pollution tolerance index and anticipated performance index of selected roadside tree species in Ludhiana, India.
Environ Monit Assess
December 2022
Department of Botany, Punjab Agricultural University, Ludhiana, India.
Air quality has deteriorated in most big cities and becoming the fifth major cause of mortality in India. Among others, vehicle gaseous emission is a major contributor. Plants have different tolerance levels, which can be identified based on Air Pollution Tolerance Index (APTI).
View Article and Find Full Text PDFBioactivity-guided isolation of anti-inflammatory limonins from .
Food Sci Nutr
December 2022
Fujian Key Laboratory of Natural Medicine Pharmacology, School of Pharmacy Fujian Medical University Fuzhou China.
is an economically important tree and widely cultured in the southeast of China. Its barks, leaves, and fruits are consumed as a traditional medicine and perceived as a valuable source for bioactive limonin compounds. The extracts from root barks of showed significant anti-inflammatory effect.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!