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Efficacy of contrast-enhanced ultrasonography in radiofrequency ablation for hepatocellular carcinoma. | LitMetric

AI Article Synopsis

  • Local recurrence after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) is a significant issue, and the study aimed to evaluate the effectiveness of contrast-enhanced ultrasound (CE-US) with Sonazoid(®) in improving treatment outcomes.
  • The study compared two groups: 31 nodules treated without CE-US and 71 with CE-US, finding that the latter group had significantly better treatment results in terms of radicality and lower local recurrence.
  • The conclusion highlights that CE-US with Sonazoid(®) enhances the precision of HCC detection before and during RFA, leading to better treatment effectiveness and reduced chances of cancer recurrence.

Article Abstract

Objective: Local recurrence after radiofrequency ablation (RFA) is a major problem that needs to resolved to increase the survival rate of hepatocellular carcinoma (HCC). CE-US with Sonazoid(®), the second-generation contrast media, can detect smaller HCC lesions and the detection rate of ultrasonically unrecognized hypervascular HCC was improved by CE-US. The aim of the present study was to evaluate the role of CE-US with Sonazoid(®) in improving radicality and reducing local recurrence after RFA for HCC.

Patients And Methods: A total of 102 nodules treated by RFA at our hospital from January 2006 to October 2009 were enrolled: 31 nodules were treated without CE-US, since CE-US was not yet available (Group A), and 71 nodules were treated with a combination of RFA and CE-US with Sonazoid(®) (Group B).

Results: The clinical characteristics (sex, virus marker, Child-Pugh grade, with or without transcatheter arterial infusion chemotherapy with lipiodol, and T factor) did not differ significantly between group A and group B. Mean age was significantly older and tumor size was significantly larger in group B. Group B had significantly better radicality compared with group A. The non-local recurrence rate was significantly higher in group B as compared with group A.

Conclusion: CE-US with Sonazoid(®) greatly helps to improve RFA efficacy in HCC treatment. We suggest that the ability of CE-US with Sonazoid(®) to detect an accurate area of HCC before RFA and to immediately detect a residual tumor during RFA might contribute to an increase of the radicality and reduction of local recurrence after RFA.

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Source
http://dx.doi.org/10.2169/internalmedicine.51.6042DOI Listing

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