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| http://dx.doi.org/10.1111/j.1752-8062.2011.00360.x | DOI Listing |
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EphrinB2-mediated CDK5/ISL1 pathway enhances cardiac lymphangiogenesis and alleviates ischemic injury by resolving post-MI inflammation.
Signal Transduct Target Ther
November 2024
Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institute of Biomedical Sciences, Fudan University, Shanghai, China.
Article Synopsis
- EphrinB2 is crucial for promoting the formation of blood and lymph vessels during embryo development and plays a significant role in cardiac lymphangiogenesis after a heart attack (myocardial infarction, MI).
- The study found that EphrinB2 helps prevent heart remodeling and dysfunction post-MI by activating pathways involved in lymphangiogenesis, with its absence leading to worsening heart conditions.
- Mechanistically, EphrinB2 enhances the proliferation and migration of lymphatic endothelial cells, boosts the activity of a specific transcription factor (ISL1), and its effects are diminished when the VEGFR3 pathway is inhibited, highlighting its importance in cardiac recovery after MI.
[Iron Metabolism and Iron Therapy in Chronic Renal Failure].
G Ital Nefrol
October 2024
UO Nefrologia Dialisi e Trapianto, ASST Grande ospedale Metropolitano Niguarda.
Iron therapy in nephropathic patients can allow optimizing treatment with EPO identifying the minimum effective dose capable of improving the patient's quality of life. The most recent studies on iron metabolism and on the interference of iron deficiency syndrome on the performance of some organs, in particular the myocardium, suggest the need to intervene very early, especially in patients with cardiomyopathy and systolic deficit. Setting up an iron therapy in nephropathic patients requires a correct diagnosis.
View Article and Find Full Text PDFEffect of perioperative erythropoietin on postoperative morbidity and mortality after cardiac surgery: a meta-analysis of randomized controlled trials.
Anaesth Crit Care Pain Med
December 2024
Department of Cardiothoracic Surgery, Carmel Medical Center, Haifa, Israel; The Ruth & Baruch Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Objective: Cardiac surgery is known to have high rates of perioperative red blood cell (RBC) transfusions which are associated with increased postoperative mortality and morbidity. Perioperative erythropoietin (EPO) has been suggested to lower perioperative RBC transfusions, and the effect on postoperative morbidity or mortality is unknown.
Methods: The registered study protocol is available on PROSPERO (CRD42022314538).
Erythropoiesis-stimulating agents for preventing acute kidney injury.
Cochrane Database Syst Rev
September 2024
Global Health Nursing, Graduate School of Nursing Science, St. Luke's International University, Tokyo, Japan.
Background: Acute kidney injury (AKI) is characterised by a rapid decline in kidney function and is caused by a variety of clinical conditions. The incidence of AKI in hospitalised adults is high. In animal studies, erythropoiesis-stimulating agents (ESA) have been shown to act as a novel nephroprotective agent against ischaemic, toxic, and septic AKI by inhibiting apoptosis, promoting cell proliferation, and inducing antioxidant and anti-inflammatory responses.
View Article and Find Full Text PDFPrognostic Role of Tissue Iron Deficiency Measured by sTfR Levels in Heart Failure Patients without Systemic Iron Deficiency or Anemia.
J Clin Med
August 2024
Bio-Heart Cardiovascular Diseases Research Group, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
. Iron deficiency (ID) is a significant, high-prevalence comorbidity in chronic heart failure (HF) that represents an independent predictor of a worse prognosis. However, a clear-cut diagnosis of ID in HF patients is not assured.
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