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Corrigendum to "Illudin S inhibits p53-Mdm2 interaction for anticancer efficacy in colorectal cancer" [Biomed. Pharmacother. 182 (2025) 117795].
Biomed Pharmacother
January 2025
Department of Chemistry, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address:
Assessing Long-Term Outcomes after Operative Management of Elbow Stiffness Secondary to Heterotopic Ossification.
J Shoulder Elbow Surg
January 2025
Department of Orthopaedic Surgery and Rehabilitation, Loyola University Health System, Maywood, IL, USA.
Article Synopsis
- Heterotopic ossification (HO) in the elbow leads to limited movement and is often caused by injuries like burns or trauma; this study analyzes the long-term outcomes of 51 elbows treated surgically.
- The study followed 48 patients over an average of 8 years, assessing metrics such as elbow movement arcs, pain levels, and functional performance scores post-surgery.
- Results showed significant improvement in elbow functionality, but patients with type II diabetes experienced the lowest movement range and higher complication rates, indicating potential risk factors for poorer outcomes.
Targeted Cx43 therapeutics reduce NLRP3 inflammasome activation in rat burn injury.
Burns
December 2024
Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, 11, Mandalay Road, 308232, Singapore; Skin Research Institute Singapore, Level 17, Clinical Sciences Building, 11, Mandalay Road, 308232, Singapore; National Skin Centre Singapore, 1 Mandalay Rd, 308205, Singapore. Electronic address:
Burns are dynamic injuries characterized by an initial zone of necrosis that progresses to compromise surrounding tissue. Acute inflammation and cell death are two main factors contributing to burn progression. These processes are modulated by Connexin43 (Cx43) hemichannels and gap junctions in burns and chronic wounds.
View Article and Find Full Text PDFMixed grafting of small auto- and cryopreserved allo-skin for residual wound repair in severe burn patients: A retrospective study.
Burns
December 2024
Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China. Electronic address:
Background: The wound repair process for extensively deep burn patients is a recurring and highly challenging endeavor. A prolonged healing time beyond 3 weeks after injury often leads to compromised healing outcomes. The limited availability of autologous skin grafts remains the primary obstacle in achieving timely wound repair.
View Article and Find Full Text PDFFeasibility of a randomized controlled trial of enteral vs intravenous resuscitation for adults with major burn injuries in Nepal.
Burns
December 2024
Department of Surgery, University of Washington School of Medicine, Seattle, WA, United States; Harborview Injury Prevention and Research Center, United States. Electronic address:
Introduction: Enterally-based resuscitation (EResus) is safe, efficacious, and has operational advantages, particularly in low-resource settings. However, there is a lack of real-world effectiveness studies and evidence-based protocols, which hinders implementation. To address this gap, we conducted a feasibility study ahead of a randomized controlled trial (RCT) of enterally based versus usual resuscitation at a tertiary burn center in Nepal which had no prior clinical trial experience.
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