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The assessment of oxidative stress in human semen: chaos and confusion in pursuit of diagnostic precision.
Reprod Biomed Online
October 2024
CellOxess Biotechnology, Research and Development, Ewing, NJ, USA.
The importance of oxidative stress in the aetiology of male infertility has occasioned numerous clinical trials designed to assess the potential of antioxidants for treating this condition. These trials have not returned definitive results, probably because they have never selected participants on the basis of oxidative stress. Clearly, if a moderate to severe state of oxidative stress does not exist in semen, antioxidants can hardly be expected to improve fertility.
View Article and Find Full Text PDFPrediction of chronic severe intestinal failure-associated liver disease by current criteria in adults: A descriptive cohort study.
JPEN J Parenter Enteral Nutr
December 2024
Intestinal Failure Unit, Salford Royal, NHS Foundation Trust, Salford, UK.
Introduction: Intestinal failure-associated liver disease covers a spectrum of conditions from mild to end-stage disease. Currently, there are 9 diagnostic criteria divided to four categories: cholestasis, steatosis, fibrosis, and unclassified. Our aim was to evaluate the application of these criteria to patients with chronic severe liver disease in patients with intestinal failure.
View Article and Find Full Text PDFAssociation between life's essential 8 and periodontitis in U.S. adults.
Sci Rep
December 2024
Cancer Center, The First Hospital of Jilin University, Changchun, 130021, China.
Periodontitis is closely related to lifestyle habits. Our objective was to examine the relationship between the Life's Essential 8 (LE8) and the prevalence of periodontitis in American adults. This study used data from the 2009-2014 National Health and Nutrition Examination Survey (NHANES).
View Article and Find Full Text PDFCognitive abilities predict naturalistic speech length in older adults.
Sci Rep
December 2024
Healthy Longevity Center, University of Zurich, Zurich, Switzerland.
Past research has demonstrated the association between social engagement and the maintenance of cognitive abilities. However, inconsistent definitions of social engagement have posed challenges to systematically investigate this association. This paper addresses the role of social relationships in cognitive functioning among older adults, focusing on the real-life communication indicator-length of own speech-as a measure of social activity.
View Article and Find Full Text PDFA randomised controlled pilot trial protocol for patient led cognitive gamified training during haemodialysis.
Sci Rep
December 2024
University of York, York, England, UK.
Disruptions in cognitive function have been reported in individuals undergoing haemodialysis and those with chronic kidney disease. This pilot study protocol primarily assesses the feasibility and acceptability of using mobile cognitive gaming apps for patient-led cognitive training during haemodialysis sessions. The protocol consists of three phases: (1) reviewing and evaluating available cognitive gaming apps, (2) conducting focus groups/interviews with people with kidney disease to determine app preferences, and (3) undertaking a quasi-experimental randomised controlled trial to compare cognitive outcomes between a patient-led app intervention group and a standard care control group over four months.
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