Jones et al. in Journal of Experimental Psychology Human Perception and Performance 21:293-307, 1995, showed that a temporal perturbation is easier to detect in a 3:2 polyrhythm than in a single-stream isochronous baseline condition if the two isochronous pulse streams forming the polyrhythm are perceptually integrated: integration creates shorter inter-onset interval (IOI) durations that facilitate perturbation detection. The present study examined whether this benefit of integration outweighs the potential costs imposed by the greater IOI heterogeneity and memory demands of more complex polyrhythms. In "Experiment 1", musically trained participants tried to detect perturbations in 3:5, 4:5, 6:5, and 7:5 polyrhythms having one of two different pitch separations between pulse streams, as well as in an isochronous baseline condition. "Experiment 2" included an additional 2:5 polyrhythm, additional pitch separations, and instructions to integrate or segregate the two pulse streams. In both experiments, perturbation detection scores for polyrhythms were below baseline, decreased as polyrhythm complexity increased, and tended to be lower at a smaller pitch separation, with little effect of instructions. Clearly, polyrhythm complexity was the main determinant of detection performance, which is attributed to the interval heterogeneity and/or memory demands of the pattern formed by the integrated pulse streams. In this task, perceptual integration was disadvantageous, but apparently could not be avoided.
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http://dx.doi.org/10.1007/s00426-011-0406-8 | DOI Listing |
JACC Cardiovasc Interv
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Department for Angiology, Brandenburg Medical School Theodor Fontane, Campus Clinic Brandenburg, Center for Internal Medicine I, Berlin, Germany; Department of Angiology, Sankt-Gertrauden-Krankenhaus, Berlin, Germany.
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Int J Mol Sci
January 2025
Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
This review describes our current understanding of the role of the mitochondria in the repurposing of the anti-diabetes drugs metformin, gliclazide, GLP-1 receptor agonists, and SGLT2 inhibitors for additional clinical benefits regarding unhealthy aging, long COVID, mental neurogenerative disorders, and obesity. Metformin, the most prominent of these diabetes drugs, has been called the "Drug of Miracles and Wonders," as clinical trials have found it to be beneficial for human patients suffering from these maladies. To promote viral replication in all infected human cells, SARS-CoV-2 stimulates the infected liver cells to produce glucose and to export it into the blood stream, which can cause diabetes in long COVID patients, and metformin, which reduces the levels of glucose in the blood, was shown to cut the incidence rate of long COVID in half for all patients recovering from SARS-CoV-2.
View Article and Find Full Text PDFAnimals (Basel)
December 2024
Department of Electrical and Computer Engineering, North Carolina State University, Raleigh, NC 27695, USA.
Canine-assisted interactions (CAIs) have been explored to offer therapeutic benefits to human participants in various contexts, from addressing cancer-related fatigue to treating post-traumatic stress disorder. Despite their widespread adoption, there are still unresolved questions regarding the outcomes for both humans and animals involved in these interactions. Previous attempts to address these questions have suffered from core methodological weaknesses, especially due to absence of tools for an efficient objective evaluation and lack of focus on the canine perspective.
View Article and Find Full Text PDFAquat Toxicol
December 2024
Department Aquatic Ecotoxicology, Goethe University Frankfurt, Max-von-Laue Straße 13, 60438 Frankfurt am Main, Germany; Kompetenzzentrum Wasser Hessen, Max-von-Laue Straße 13, 60438 Frankfurt am Main, Germany.
Based on effect data, regulatory acceptable concentrations (RACs) are derived for surface waters to avoid unacceptable effects on the environment. RACs often relay on acute tests with single species, which may underestimate the effects under field conditions. Therefore, we applied a higher tier approach with artificial indoor streams (AIS).
View Article and Find Full Text PDFPLoS One
December 2024
Department of Computer Science, College of Computing and Information Technology, Shaqra University, Shaqra, Saudi Arabia.
Biometric stress monitoring has become a critical area of research in understanding and managing health problems resulting from stress. One of the fields that emerged in this area is biometric stress monitoring, which provides continuous or real-time information about different anxiety levels among people by analyzing physiological signals and behavioral data. In this paper, we propose a new approach based on the CapsNets model for continuously monitoring psychophysiological stress.
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