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Variability in the Evaluation and Treatment of Healthy Neonates With Uncomplicated Conjunctivitis.
J Pediatr Ophthalmol Strabismus
December 2024
Purpose: To explore the current state of diagnosis and management of neonatal conjunctivitis.
Methods: Cosmos, an EHR-based, de-identified data set including more than 200 million patients, was used for this study. Neonates born between January 1, 2016 and December 31, 2022, discharged from the hospital by day 3 of life, and with an ambulatory visit within the first 4 weeks of life associated with a new diagnosis of neonatal conjunctivitis (SNOMED) or conjunctivitis (ICD-10 H10.
Draft whole-genome sequence of isolate from a clinical sample from Dhaka, Bangladesh.
Microbiol Resour Announc
December 2024
Infectious Disease Division, International Center for Diarrheal Disease Research, Dhaka, Bangladesh.
We collected a urine specimen from a 20-year-old male, cultured it on Chrom-agar , identified it with VITEK2, and whole-genome sequenced it using the PacBio RSII. The genome was 3,111,621 nucleotides long with a GC% of 37.6%.
View Article and Find Full Text PDFBacterial Communities and Their Role in Bacterial Infections.
Front Biosci (Elite Ed)
December 2024
Institute of Biochemistry and Physiology of Plants and Microorganisms - Subdivision of the Federal State Budgetary Research Institution Saratov Federal Scientific Centre of the Russian Academy of Sciences (IBPPM RAS), 410049 Saratov, Russia.
Since infections associated with microbial communities threaten human health, research is increasingly focusing on the development of biofilms and strategies to combat them. Bacterial communities may include bacteria of one or several species. Therefore, examining all the microbes and identifying individual community bacteria responsible for the infectious process is important.
View Article and Find Full Text PDFGallic Acid: A Potent Metabolite Targeting Shikimate Kinase in .
Metabolites
December 2024
Pharmacognosy and Pharmaceutical Chemistry Department, Faculty of Pharmacy, Taibah University, Al Madinah Al Munawarah 30001, Saudi Arabia.
is a highly multidrug-resistant pathogen resistant to almost all classes of antibiotics; new therapeutic strategies against this infectious agent are urgently needed. Shikimate kinase is an enzyme belonging to the shikimate pathway and has become a potential target for drug development. This work describes the search for Food and Drug Administration (FDA)-approved drugs and natural compounds, including gallic acid, that could be repurposed as selective shikimate kinase inhibitors by integrated computational and experimental approaches.
View Article and Find Full Text PDFTreatment of Complicated Gram-Positive Bacteremia and Infective Endocarditis.
Drugs
December 2024
Institute for Infectious Disease and Infection Control, Jena University Hospital, Friedrich-Schiller-University, Am Klinikum 1, 07749, Jena, Germany.
The Gram-positive cocci Staphylococcus aureus, Streptococcus spp., and Enterococcus spp. are the most frequent causative organisms of bloodstream infections and infective endocarditis.
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