[Tooth and bone research using genetically modified mice].

Clin Calcium

Department of Human Development and Fostering, Meikai University School of Dentistry, Saitama, Japan.

Published: January 2012

Teeth and bone are both hard tissues and composed of hydroxyapatite. Tooth development initiates with the invasination of oral epithelium, followed by aggregation of supporting ectomesenchymal cells. From mouse study, numbers of molecules have been discovered to relate tooth development. These discoveries have helped to clarify the responsible genes of human genetic disorders with abnormal tooth number and structure. During tooth development, teeth erupt into the outer environment, oral cavity. From this point, teeth are completely different from bone which is always covered by soft tissues. Tooth eruption is composed of two different processes, that is, eruption pathway formation and vertical tooth movement. In this review, mutant mice with abnormal tooth development and eruption are introduced, and molecular mechanism required for this process is discussed.

Download full-text PDF

Source

Publication Analysis

Top Keywords

tooth development
16
abnormal tooth
8
tooth
7
[tooth bone
4
bone genetically
4
genetically modified
4
modified mice]
4
mice] teeth
4
teeth bone
4
bone hard
4

Similar Publications

Assessment of using transfer learning with different classifiers in hypodontia diagnosis.

BMC Oral Health

January 2025

Pediatric Dentistry Department, Faculty of Dentistry, Başkent University, 06490, Ankara, Turkey.

Background: Hypodontia is the absence of one or more teeth in the primary or permanent dentition during development, and radiographic imaging is the most common method of diagnosis. However, in recent years, artificial intelligence-based decision support systems have been employed to make highly accurate diagnoses. The aim of this study was to classify single premolar agenesis, multiple premolar agenesis, and without tooth agenesis using various artificial intelligence approaches.

View Article and Find Full Text PDF

In vitro analysis of composition profiles of resins for 3D printing of dentures.

J Dent

January 2025

Clinic of General-, Special Care- and Geriatric Dentistry, Center for Dental Medicine, University of Zurich, Zurich, Switzerland. Electronic address:

Objective: This study aimed to investigate the resin compounds from CAD-CAM 3D-printed denture resins, focusing on the identification and classification of free monomers and other components. The primary objective was to determine the chemical profile of these 3D-prinding resin materials.

Methods: Four 3D-printed denture resins, two base materials (1: DentaBASE, Asiga Ltd.

View Article and Find Full Text PDF

Objectives: To evaluate the effect of orthodontic movement on traumatized teeth treated with the regenerative endodontic procedure (REP).

Materials And Methods: The increase of the radiographic root area (RRA) of each REP tooth was measured at each follow-up visit after the end of orthodontic treatment. The study included two experimental groups of patients aged 7-17 with REP-treated teeth.

View Article and Find Full Text PDF

Prevalence and type of removable prostheses manufactured in dental laboratories in Switzerland over the last 10 years.

Swiss Dent J

January 2025

Division of Gerodontology and Removable Prosthodontics, University Clinics of Dental Medicine, University of Geneva, Geneva, Switzerland.

Due to effective preventive measures and advanced techniques in operative dentistry, tooth loss occurs later in life and implant restorations have become a common solution for replacement of missing teeth. Therefore, the use of removable dental prostheses (RDPs) is expected to decline over time. This study aims to evaluate the expected decrease in the production of RDPs in Swiss dental laboratories over the past decade.

View Article and Find Full Text PDF

RNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such as N6-methyladenosine (mA) and 5-methylcytosine (mC), are implicated in various cellular processes. These modifications are regulated by proteins that write, erase, and read RNA and modulate RNA stability, splicing, translation, and degradation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!