A new study reports the development of the 'morbidostat', a device that allows for continuous culture of bacteria under a constant drug selection pressure using computer feedback control of antibiotic concentration. This device, together with bacterial whole-genome sequencing, allowed the authors to follow the evolution of resistance-conferring mutations in Escherichia coli populations in real time, providing support for deterministic evolution of resistance in some situations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/ng.1048 | DOI Listing |
Publication Analysis
Top Keywords
real time
8
evolution bacterial
4
bacterial antibiotic
4
antibiotic resistance
4
resistance real
4
time study
4
study reports
4
reports development
4
development 'morbidostat'
4
'morbidostat' device
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!