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TGF-β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia.
J Pathol
July 2024
Section of Pathology, Department of Morphological Biology, Division of Biomedical Sciences, Fukuoka Dental College, Fukuoka, Japan.
Article Synopsis
- - Necrotising sialometaplasia (NSM) is a non-cancerous growth mostly found in the minor salivary glands, presenting as swelling and potentially ulceration, often mimicking cancer like squamous cell carcinoma.
- - Histopathologically, NSM is characterized by lobular structures, acinar infarction, and changes in the salivary ducts, with an unknown cause that requires careful distinction from malignant conditions.
- - The study investigates the role of the TGF-β3 gene, finding that it is upregulated in NSM and may contribute to the condition by inhibiting cell growth and causing cell type changes during healing and tissue regeneration.
Necrotizing sialometaplasia on the hard palate after sequential induced vomiting: case study.
Braz J Otorhinolaryngol
April 2024
Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
Article Synopsis
- * The condition usually affects minor salivary glands, particularly in the hard palate, but can occur in other areas with salivary tissue.
- * Local ischemia, often caused by dental procedures and anesthesia in the palate, is believed to be the main factor behind this condition's development.
Non-Ulcerated and Ulcerated Necrotizing Sialometaplasia: Report of an Additional Case and Literature Review.
Indian J Otolaryngol Head Neck Surg
September 2023
Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Avenida do Caf?, S/N, 14040-904 Ribeirão Preto, SP Brazil.
Article Synopsis
- Necrotizing sialometaplasia (NS) is a rare, self-limiting condition that mainly affects the minor salivary glands in the palate and is more common in men over 45 years old.
- *It typically appears as an ulcerative lesion but can also be non-ulcerated, making it critical to include in diagnoses when examining oral lesions.
- *A case involving a 50-year-old male with a non-ulcerated lesion on the hard palate highlighted differences in age and gender prevalence compared to traditional ulcerated cases, emphasizing the unique characteristics of NS.
Simultaneous presentation of dual pathologies within the oral cavity: an unusual and diagnostically challenging presentation.
Br Dent J
August 2023
School of Dentistry, University of Birmingham, Birmingham, UK; Periodontal Research Group, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom.
Article Synopsis
- - Necrotising sialometaplasia (NS) is a rare condition with limited understanding of its causes and effects, making diagnosis complex and essential for ruling out oral cancer.
- - A case study from Birmingham Dental Hospital involved a 22-year-old South Asian woman who experienced pain linked to her lower right third molar, initially misdiagnosed as a viral infection, but was ultimately found to have both NS and pericoronitis.
- - This report highlights the unique diagnosis and management of non-ulcerating NS along with pericoronitis, a combination not previously documented in scientific literature, showcasing the intricacies of diagnosing rare oral conditions.
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