Pathohistologic examinations of the peripheral lymph nodes in 14 patients with abscessed acne, chronic infiltrative ulcerous and infiltrative fistulous pyoderma coursing for 1 to 11 years have revealed that chronic pyococcal infection induces manifest atrophic and sclerotic changes in the cortical and medullary layers of the regional lymph nodes and of those distant from foci of involvement; these changes are accompanied by essential impairments of the immunologic, lymphopoietic, and other functions.
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