A convenient and scalable four-step novel route has been developed for the synthesis of rosiglitazone (8), an antidiabetic drug. This multistep route requires 4-fluoro benzaldehyde (4), 2,4-thiazolidinedione (6) and 2-chloro pyridine (1) as key reactants and gives overall better yield of rosiglitazone. In addition, some steps have been accelerated, which leads to an overall time saving of 10h.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2011.12.020 | DOI Listing |
Publication Analysis
Top Keywords
antidiabetic drug
8
alternative synthetic
4
synthetic route
4
route antidiabetic
4
drug rosiglitazone
4
rosiglitazone convenient
4
convenient scalable
4
scalable four-step
4
four-step novel
4
novel route
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!