Brain metastases originating from pancreatic cancer are associated with a dismal prognosis and, generally, therapeutic options remain palliative. We present the cases of two patients that developed brain metastases after resection of a pancreatic ductal adenocarcinoma. Brain metastases were resected successfully and neither patients developed any further tumor recurrence. These cases demonstrate that resection of brain metastatic lesions originating from pancreatic ductal adenocarcinoma is a reasonable therapeutic option with a chance for complete cure in some cases.
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