Background: The epithelial to mesenchymal transition (EMT) is an important contributor to the invasion and metastasis of epithelial cell-derived cancer. However, whether or not the expression of EMT-related molecules can be used as a biomarker for the prognosis of lung cancer has yet to be fully determined.
Patients And Methods: Tumor specimens were collected from 183 consecutive patients who underwent a complete resection for lung adenocarcinoma. We analyzed the E-cadherin, gamma-catenin, vimentin, and fibronectin expression levels in the primary lung adenocarcinoma by immunohistochemical analysis.
Results: A positive expression of E-cadherin, gamma-catenin, vimentin, and fibronectin was observed in 94 (51.4%), 82 (40.4%), 32 (17.5%) and 1 (0.5%) patient, respectively. A significant association between E-cadherin expression and the pathological stage, T status, N status, tumor grade, and carcinoembryonic antigen was identified. The rate of gamma-catenin positivity was higher in patients with a smoking history than in never smokers. Moreover, a significant correlation was observed between vimentin expression and the pathological stage, N status, and tumor grade. However, an association between EMT-related molecules and postoperative recurrence of lung adenocarcinoma is lacking. Based on a Kaplan-Meier analysis, the expression of EMT-related molecules is not associated with the survival of lung adenocarcinoma patients.
Conclusion: The EMT status in the primary tumor does not predict postoperative recurrence or disease-free survival in lung cancer patients. Our findings indicate that immunocytochemical markers related to EMT do not provide relevant prognostic information about lung adenocarcinoma. Future research is therefore expected to clarify the clinical usefulness of EMT-related molecules.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Combination of Carbonic Anhydrase Isoform IX Inhibitors and Gefitinib Suppresses on the Invasive Potential of Non-Small Cell Lung Cancer Cells.
Biochemistry (Mosc)
December 2024
Medicinal Chemistry Center, Togliatti State University, Togliatti, 445020, Russia.
Human carbonic anhydrase IX (CAIX) plays a key role in maintaining pH homeostasis of malignant neoplasms, thus creating a favorable microenvironment for the growth, invasion, and metastasis of tumor cells. Recent studies have established that inhibition of CAIX expressed on the surface of tumor cells significantly increases the efficacy of classical chemotherapeutic agents and makes it possible to suppress the resistance of tumor cells to chemotherapy, as well as to increase their sensitivity to drugs (in particular, to reduce the required dose of cytostatic agents). In this work, we studied the ability of new CAIX inhibitors based on substituted 1,2,4-oxadiazole-containing primary aromatic sulfonamides, to potentiate the cytostatic effect of gefitinib (selective inhibitor of epidermal growth factor receptor tyrosine kinase domain) under hypoxic conditions.
View Article and Find Full Text PDFActivation of P38 MAPK Signaling Cascade is Linked with Clinical Outcomes and Therapeutic Responses in Human Cancers.
Biochemistry (Mosc)
December 2024
Moscow Institute of Physics and Technology, Dolgoprudny, 141701, Russia.
Activation of the p38 mitogen-activated protein kinase (MAPK) pathways is vital in regulating cell growth, differentiation, apoptosis, and stress response, significantly affecting tumorigenesis and cancer progression. We developed a bioinformatic technique to construct an interactome network-based molecular pathways for genes of interest and quantify their activation levels using high-throughput gene expression data. This study is focused on the p38α, p38β, p38γ, and p38δ kinases, examining their activation levels (PALs) based on transcriptomic data and their associations with survival and drug responsiveness across various cancer types.
View Article and Find Full Text PDF[Effect of SMARCA4 mutations on the outcomes of patients with advanced EGFR mutant lung adenocarcinoma].
Zhonghua Yi Xue Za Zhi
January 2025
Department of Medical Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing210000, China.
To investigate the impact of SMARCA4 mutations on the outcomes of patients with advanced lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations. In the Memorial Sloan Kettering Cancer Center (MSK) MetTropism study, 960 patients with advanced EGFR-mutated lung adenocarcinoma were screened and included in the MSK cohort, composing of 313 males and 647 females, with a median [(, )] age of 64 (56, 72) years. A retrospective analysis was conducted on the data of 178 patients with advanced EGFR-mutated lung adenocarcinoma who received EGFR tyrosine kinase inhibitors (TKIs) treatment in the Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, from January 2018 to December 2022.
View Article and Find Full Text PDF[Development and validation of a nomogram combining clinical and F-FDG PET/CT parameters for prediction of high-grade patterns in invasive lung adenocarcinoma].
Zhonghua Yi Xue Za Zhi
January 2025
Department of Nuclear Medicine, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing100730, China.
To establish and validate a nomogram based on clinical characteristics and metabolic parameters derived from F-fluorodeoxyglucose positron emission tomography and computed tomography (F-FDG PET/CT) for prediction of high-grade patterns (HGP) in invasive lung adenocarcinoma. The clinical and PET/CT image data of 311 patients who were confirmed invasive lung adenocarcinoma and underwent pre-treatment F-FDG PET/CT scan in Beijing Hospital between October 2017 and March 2022 were retrospectively collected. The enrolled patients were divided into HGP group (196 patients) and non-HGP group (115 patients) according to the presence and absence of HGP.
View Article and Find Full Text PDFPredictive value and mechanism of lncRNA MANCR for pediatric severe pneumonia via miR-20a-5p / MAPK1 axis.
Immunobiology
January 2025
Department of Pediatrics, Chinese and Western Medicine Hospital of Panzhihua, Panzhihua 617099, China.
Severe community-acquired pneumonia (SCAP) significantly threats the safety of children's lives. Long non-coding RNA (lncRNA) MANCR is overexpressed in lung adenocarcinoma (LUAD) tissue, promote the proliferation, invasion, and migration, decreased cell apoptosis of LUAD cells. This study aimed to detect lncRNA MANCR levels in pediatric SCAP, and explore the diagnostic and prognostic significance of MANCR in pediatric SCAP.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!