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Nasolabial Transfer Flap with Auricular Cartilage Graft after Fat Grafting for Nasal Ala Reconstruction in Parry-Romberg Syndrome.

Aesthetic Plast Surg

October 2024

Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, 510515, Guangdong, People's Republic of China.

Background: Alar atrophy associated with Parry-Romberg syndrome (PRS) can lead to significant nasal contour deformities. The primary objective of this study was to address nasal alar deformities in PRS patients through the application of a nasolabial transfer flap combined with an auricular cartilage graft after sequential fat grafting.

Methods: All PRS patients with alar deformities who underwent our reconstructive surgery were included in this case series.

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Parry Romberg syndrome (PRS) is a rare self-limiting disease, typically occurring in children and young adults, that causes slow progressive atrophy of one-half of the face. It primarily affects the subcutaneous tissue and skin with some cases exhibiting deeper extension to glandular, osseous and muscular structures. Neurologic and ocular involvement is variable.

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Parry-Romberg syndrome (PRS), also recognized as progressive hemifacial atrophy (PHA), is a rare medical condition affecting the dermis, subcutaneous tissue, and occasionally underlying anatomical structures such as muscles and bones. While the etiology of this condition remains incompletely elucidated, it has been hypothesized that trauma, autoimmunity, infection, and autonomic dysregulation may constitute potential contributory factors. Typically, the onset of symptoms occurs within the initial two decades of life, though instances of late-onset PRS manifesting in the sixth and seventh decades of life have also been documented.

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Challenges and complications in juvenile localized scleroderma: A practical approach.

Best Pract Res Clin Rheumatol

September 2024

Division of Pediatric Rheumatology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, USA; Department of Pediatrics, University of Pittsburgh School of Medicine, University of Pittsburgh Scleroderma Center, 4401 Penn Ave Pittsburgh, Pennsylvania, USA, 15224. Electronic address:

Article Synopsis
  • - Juvenile localized scleroderma leads to skin and soft tissue fibrosis, often resulting in more severe forms like linear and craniofacial scleroderma in children.
  • - About 50% of affected children experience extracutaneous symptoms, which can worsen treatment outcomes and overall quality of life.
  • - The review aims to tackle the management challenges of these severe cases by presenting case studies, available evidence, and current treatment recommendations.
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Article Synopsis
  • Parry-Romberg syndrome is a rare condition that leads to progressive shrinkage of one side of the face, with significant effects on a person's appearance and mental health.
  • The case report discusses a 14-year-old girl with a history of linear morphea who experienced seizures and was ultimately diagnosed with Parry-Romberg syndrome.
  • It emphasizes the importance of a coordinated approach among different specialists, including rheumatologists, dermatologists, neurologists, and ophthalmologists, in the comprehensive management of the syndrome.
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