Additional drug resistance in Mycobacterium tuberculosis isolates from resected cavities among patients with multidrug-resistant or extensively drug-resistant pulmonary tuberculosis.

Russell R Kempker Alexander S Rabin Ketino Nikolaishvili Iagor Kalandadze Shota Gogishvili Henry M Blumberg Sergo Vashakidze

Clin Infect Dis

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA.

Published: March 2012

The pathogenesis of increasing drug resistance among patients with multidrug-resistant or extensively drug-resistant tuberculosis undergoing treatment is poorly understood. Increasing drug resistance found among Mycobacterium tuberculosis recovered from cavitary isolates compared with paired sputum isolates suggests pulmonary cavities may play a role in the development of worsening tuberculosis drug resistance.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284212	PMC
http://dx.doi.org/10.1093/cid/cir904	DOI Listing

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