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The Diagnostic Accuracy of Claudin-4 Immunochemistry in Differentiating Metastatic Carcinomas From Mesothelial Processes in Serous Effusion Cytology: A Systematic Review and Meta-analysis.
Arch Pathol Lab Med
June 2024
From School of Medicine, European University Cyprus, Nicosia, Cyprus (Kleinaki, Ishak, Arnaouti, Nikas).
Context.—: Distinguishing metastatic carcinomas from mesotheliomas or reactive mesothelial cells in pleural, peritoneal, and pericardial effusions is a common diagnostic problem cytopathologists encounter.
Objective.
The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma.
Hum Exp Toxicol
November 2021
Department of Pharmaceutical Toxicology, Faculty of Pharmacy, 37520İnönü University, Malatya, Turkey.
Article Synopsis
- Malignant pleural mesothelioma (MPM) is a serious cancer mainly linked to asbestos exposure, and this study investigates noninvasive biomarkers for its diagnosis.
- A total of 30 MPM patients and 25 control subjects were analyzed, with biomarker levels measured through an enzyme immunoassay and statistical tests applied to evaluate the results.
- The study found that several biomarkers (neopterin, periostin, YKL-40, Tenascin-C, and IDO) were significantly higher in MPM patients compared to controls, suggesting they could be useful for early diagnosis of MPM.
Rapid on-site evaluation with the Hemacolor rapid staining method of medical thoracoscopy biopsy specimens for the management of pleural disease.
Respirology
August 2016
Pulmonary Department, Nicosia General Hospital, Nicosia, Cyprus.
Background And Objective: Medical thoracoscopy (MT) is useful for the management of pleural disease. Rapid on-site evaluation (ROSE) of transbronchial needle aspirates proved to be useful during bronchoscopy. We aimed to evaluate the diagnostic performance of ROSE of MT biopsy specimens and thoracoscopists' impression of the macroscopic appearance and assess the intermodality agreement between ROSE and final histopathologic diagnosis.
View Article and Find Full Text PDFA rare clinical case - Solitary fibrous tumor of the pleura.
Respir Med Case Rep
January 2016
Department of Respiratory Medicine, Nicosia General Hospital, Cyprus.
We present a case of a 58 years old man with a large heterogeneous and well circumscribed soft tissue mass arising from the right pleural surface, found at a computer tomography of his chest. This mass after complete resection through a right lateral open thoracotomy, proved to be a Solitary Fibrous Tumor, previously known as 'benign mesothelioma'. This tumor is usually discovered at routine chest X-rays since patients are either asymptomatic or report atypical symptoms.
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