AI Article Synopsis
- Sirtuins play an important role in connecting energy levels to how cells metabolize substances.
- Research by Libert et al. suggests that SIRT1 activity in the brain influences emotional behavior in mammals by affecting monoamine signaling.
- Alterations in this signaling pathway might be linked to emotional disorders in humans.
Article Abstract
Sirtuins are thought to form crucial links between energy levels and cellular metabolism. Libert et al. now provide evidence that SIRT1 activity in the brain modifies mammalian emotional behavior via monoamine signaling and that changes in this pathway might contribute to human affective disorders.
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| http://dx.doi.org/10.1016/j.cell.2011.11.052 | DOI Listing |
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