Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells. | LitMetric

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Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells. | LitMetric

Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells.

Almut Schulze Julian Downward

Mol Cell

Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, London WC2A 3LY, UK.

Published: December 2011

In this issue of Molecular Cell, Hitosugi et al. (2011) show that the switch from oxidative phosphorylation to glycolysis in cancer cells is regulated by tyrosine phosphorylation of PDHK1.

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http://dx.doi.org/10.1016/j.molcel.2011.12.004	DOI Listing

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