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Grupo Prometheus y Biomedicina Aplicada a las Ciencias Clinicas, School of Medicine, Universidad de Cartagena, Cartagena, Colombia.

Typhoid fever (enteric fever), caused by Salmonella enterica subsp. enterica serovar Typhi (S. Typhi), is a public health problem especially in South Asia and sub-Saharan African countries, while incidence remains low in most other parts of the world, where the disease is primary related to recent travel to endemic countries or contact with chronic carriers.

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Article Synopsis
  • Ileal perforation is a serious complication of typhoid fever, often leading to fatality, especially when combined with acute psychosis and late medical intervention.
  • A case involving a 19-year-old patient with sickle cell disease experiencing both ileal perforation and psychosis highlights the unpredictable nature of such complex clinical scenarios.
  • Improving socioeconomic conditions in low-income countries could help prevent typhoid fever and its deadly complications, emphasizing the need for better healthcare access.
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